Literature DB >> 2443238

Hypomethylation of DNA in pathological conditions of the human prostate.

M T Bedford1, P D van Helden.   

Abstract

The overall 5-methylcytosine content of DNA from normal, benign hyperplastic, and neoplastic human prostate tissue was analyzed. DNA methylation levels were significantly lower in prostates with benign prostatic hyperplasia and metastatic tumors. In contrast, nonmetastatic prostate tumor DNA had a 5-methylcytosine content essentially the same as in normal tissue. The results suggest a correlation between hypomethylation and metastatic capacity.

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Year:  1987        PMID： 2443238

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  60 in total

1.  The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

Authors:  C De Smet; O De Backer; I Faraoni; C Lurquin; F Brasseur; T Boon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

Review 2.  Epigenetic susceptibility factors for prostate cancer with aging.

Authors:  N A Damaschke; B Yang; S Bhusari; J P Svaren; D F Jarrard
Journal:  Prostate       Date:  2013-09-02       Impact factor: 4.104

Review 3.  Cancer epigenetics: above and beyond.

Authors:  Mariana Brait; David Sidransky
Journal:  Toxicol Mech Methods       Date:  2011-05       Impact factor: 2.987

Review 4.  Global DNA hypomethylation in prostate cancer development and progression: a systematic review.

Authors:  R Zelic; V Fiano; C Grasso; D Zugna; A Pettersson; A Gillio-Tos; F Merletti; L Richiardi
Journal:  Prostate Cancer Prostatic Dis       Date:  2014-11-11       Impact factor: 5.554

Review 5.  DNA methylation in development and disease: an overview for prostate researchers.

Authors:  Diya B Joseph; Douglas W Strand; Chad M Vezina
Journal:  Am J Clin Exp Urol       Date:  2018-12-20

6.  Epigenomic alterations in localized and advanced prostate cancer.

Authors:  Pei-Chun Lin; Eugenia G Giannopoulou; Kyung Park; Juan Miguel Mosquera; Andrea Sboner; Ashutosh K Tewari; Levi A Garraway; Himisha Beltran; Mark A Rubin; Olivier Elemento
Journal:  Neoplasia       Date:  2013-04       Impact factor: 5.715

Review 7.  Dietary factors and epigenetic regulation for prostate cancer prevention.

Authors:  Emily Ho; Laura M Beaver; David E Williams; Roderick H Dashwood
Journal:  Adv Nutr       Date:  2011-11-03       Impact factor: 8.701

Review 8.  Nitric oxide: perspectives and emerging studies of a well known cytotoxin.

Authors:  William A Paradise; Benjamin J Vesper; Ajay Goel; Joshua D Waltonen; Kenneth W Altman; G Kenneth Haines; James A Radosevich
Journal:  Int J Mol Sci       Date:  2010-07-16       Impact factor: 5.923

Review 9.  DNA methylation in hepatocellular carcinoma.

Authors:  Iris Tischoff; Andrea Tannapfe
Journal:  World J Gastroenterol       Date:  2008-03-21       Impact factor: 5.742

10.  Cause and consequences of genetic and epigenetic alterations in human cancer.

Authors:  B Sadikovic; K Al-Romaih; J A Squire; M Zielenska
Journal:  Curr Genomics       Date:  2008-09       Impact factor: 2.236
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