Literature DB >> 18350605

DNA methylation in hepatocellular carcinoma.

Iris Tischoff1, Andrea Tannapfe.   

Abstract

As for many other tumors, development of hepatocellular carcinoma (HCC) must be understood as a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes, leading to activation of oncogenes and inactivation or loss of tumor suppressor genes (TSG). In the last decades, in addition to genetic alterations, epigenetic inactivation of (tumor suppressor) genes by promoter hypermethylation has been recognized as an important and alternative mechanism in tumorigenesis. In HCC, aberrant methylation of promoter sequences occurs not only in advanced tumors, it has been also observed in premalignant conditions just as chronic viral hepatitis B or C and cirrhotic liver. This review discusses the epigenetic alterations in hepatocellular carcinoma focusing DNA methylation.

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Year:  2008        PMID： 18350605      PMCID： PMC2695914          DOI： 10.3748/wjg.14.1741

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  112 in total

1.  Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.

Authors:  Y Saito; Y Kanai; M Sakamoto; H Saito; H Ishii; S Hirohashi
Journal:  Hepatology       Date:  2001-03       Impact factor: 17.425

Review 2.  X-chromosome inactivation and cell memory.

Authors:  A D Riggs; G P Pfeifer
Journal:  Trends Genet       Date:  1992-05       Impact factor: 11.639

3.  Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.

Authors:  Hideyuki Miyoshi; Hajime Fujie; Kyoji Moriya; Yoshizumi Shintani; Takeya Tsutsumi; Masatoshi Makuuchi; Satoshi Kimura; Kazuhiko Koike
Journal:  J Gastroenterol       Date:  2004-06       Impact factor: 7.527

4.  Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers.

Authors:  Angelo Agathanggelou; Ashraf Dallol; Sabine Zöchbauer-Müller; Catherine Morrissey; Sofia Honorio; Luke Hesson; Tommy Martinsson; Kwun M Fong; Michael J Kuo; Po Wing Yuen; Eamonn R Maher; John D Minna; Farida Latif
Journal:  Oncogene       Date:  2003-03-13       Impact factor: 9.867

5.  Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas.

Authors:  T Matsumura; R Makino; K Mitamura
Journal:  Clin Cancer Res       Date:  2001-03       Impact factor: 12.531

6.  Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma.

Authors:  Yu-jing Zhang; Yu Chen; Habibul Ahsan; Ruth M Lunn; Shu-Yuan Chen; Po-huang Lee; Chien-Jen Chen; Regina M Santella
Journal:  Cancer Lett       Date:  2005-04-28       Impact factor: 8.679

7.  [Correlations of CpG island methylator phenotype and OPCML gene methylation to carcinogenesis of hepatocellular carcinoma].

Authors:  Wen-Ji Liu; Li Wang; Jian-Ping Wang; Jin-Qing Li; Chang-Qin Zhang; Lie Zheng; Yun-Fei Yuan
Journal:  Ai Zheng       Date:  2006-06

8.  Correlation between DNA methylation and pathological changes in human hepatocellular carcinoma.

Authors:  L Shen; J Fang; D Qiu; T Zhang; J Yang; S Chen; S Xiao
Journal:  Hepatogastroenterology       Date:  1998 Sep-Oct

9.  Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma.

Authors:  Pei-Fen Su; Te-Chang Lee; Pei-Ju Lin; Po-Huang Lee; Yung-Ming Jeng; Chien-Hung Chen; Ja-Der Liang; Ling-Ling Chiou; Guan-Tarn Huang; Hsuan-Shu Lee
Journal:  Int J Cancer       Date:  2007-09-15       Impact factor: 7.396

10.  Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer.

Authors:  Arvind Virmani; Asha Rathi; Kenji Sugio; Ubaradka G Sathyanarayana; Shinichi Toyooka; Frank C Kischel; Vijay Tonk; Asha Padar; Takashi Takahashi; Jack A Roth; David M Euhus; John D Minna; Adi F Gazdar
Journal:  Int J Cancer       Date:  2003-08-20       Impact factor: 7.396
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  74 in total

1.  Aberrant methylation and downregulation of sall3 in human hepatocellular carcinoma.

Authors:  Xue-Xi Yang; Jing-Zhe Sun; Fen-Xia Li; Ying-Song Wu; Hong-Yan Du; Wei Zhu; Xiang-Hong Li; Ming Li
Journal:  World J Gastroenterol       Date:  2012-06-07       Impact factor: 5.742

Review 2.  Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.

Authors:  Igor P Pogribny; Ivan Rusyn
Journal:  Cancer Lett       Date:  2012-02-02       Impact factor: 8.679

3.  DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.

Authors:  Hongyan Liu; Huijia Dong; Keith Robertson; Chen Liu
Journal:  Am J Pathol       Date:  2011-02       Impact factor: 4.307

4.  Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma.

Authors:  Philippe Couvert; Alain Carrié; Jacques Pariès; Jenny Vaysse; Audrey Miroglio; Antoine Kerjean; Pierre Nahon; Jamel Chelly; Jean-Claude Trinchet; Michel Beaugrand; Nathalie Ganne-Carrié
Journal:  World J Gastroenterol       Date:  2008-09-21       Impact factor: 5.742

Review 5.  Epigenetics, development, and cancer: zebrafish make their mark..

Authors:  Raksha Mudbhary; Kirsten C Sadler
Journal:  Birth Defects Res C Embryo Today       Date:  2011-06

6.  "Testing your methyl": DNA methylation profiling of serum DNA of HCC patients.

Authors:  Thomas Tu; Nicholas A Shackel; Geoffrey McCaughan
Journal:  Hepatol Int       Date:  2013-09-10       Impact factor: 6.047

7.  Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors.

Authors:  Hector Hernandez-Vargas; Marie-Pierre Lambert; Florence Le Calvez-Kelm; Géraldine Gouysse; Sandrine McKay-Chopin; Sean V Tavtigian; Jean-Yves Scoazec; Zdenko Herceg
Journal:  PLoS One       Date:  2010-03-17       Impact factor: 3.240

8.  Identification of novel methylation markers in hepatocellular carcinoma using a methylation array.

Authors:  So Hyun Shin; Baek-hui Kim; Ja-June Jang; Kyung Suk Suh; Gyeong Hoon Kang
Journal:  J Korean Med Sci       Date:  2010-07-20       Impact factor: 2.153

Review 9.  Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis.

Authors:  Yi Tian; Weibing Yang; Jianxun Song; Yuzhang Wu; Bing Ni
Journal:  Mol Cell Biol       Date:  2013-05-28       Impact factor: 4.272

10.  Novel therapeutic approaches for hepatocellulcar carcinoma: fact and fiction.

Authors:  Yuan-Yuan Zhang; Harry-Hua-Xiang Xia
Journal:  World J Gastroenterol       Date:  2008-03-21       Impact factor: 5.742
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