Literature DB >> 24432208

Insufficient serum caspofungin levels in a paediatric patient on ECMO.

Birgit C P Koch1, Enno D Wildschut2, Anna L de Goede1, Matthijs de Hoog2, Roger J M Brüggemann3.   

Abstract

Caspofungin, aechinocandin, is a relatively new lipophilic antifungal drug. Little is known concerning the pharmacokinetics of caspofungin in children. Extracorporeal membrane oxygenation (ECMO) allows prolonged cardiopulmonary support in patients with life-threatening respiratory or cardiac failure. Pharmacokinetics may be altered by ECMO. We describe the case of a paediatric patient on ECMO with severe pneumonia and sepsis, who had subtherapeutic exposure of caspofungin despite normal to high dosages of caspofungin. Therapeutic drug monitoring is warranted.

Entities:  

Keywords:  Aspergillosis; Candidiasis; Pharmacokinetics; Pneumonia; Therapeutic drug monitoring

Year:  2012        PMID： 24432208      PMCID： PMC3885930          DOI： 10.1016/j.mmcr.2012.12.006

Source DB:  PubMed          Journal:  Med Mycol Case Rep        ISSN： 2211-7539


  10 in total

Review 1.  Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO).

Authors:  E D Wildschut; M J Ahsman; R J Houmes; P Pokorna; S N de Wildt; R A A Mathot; D Tibboel
Journal:  Curr Drug Metab       Date:  2012-07       Impact factor: 3.731

2.  Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation.

Authors:  Maurice J Ahsman; Enno D Wildschut; Dick Tibboel; Ron A Mathot
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

3.  Potential voriconazole and caspofungin sequestration during extracorporeal membrane oxygenation.

Authors:  Stéphanie Ruiz; Emmanuelle Papy; Daniel Da Silva; Patrick Nataf; Laurent Massias; Michel Wolff; Lila Bouadma
Journal:  Intensive Care Med       Date:  2008-09-16       Impact factor: 17.440

4.  Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates.

Authors:  Maurice J Ahsman; Manon Hanekamp; Enno D Wildschut; Dick Tibboel; Ron A A Mathot
Journal:  Clin Pharmacokinet       Date:  2010-06       Impact factor: 6.447

5.  Population pharmacokinetics and pharmacodynamics of caspofungin in pediatric patients.

Authors:  Chi-Chung Li; Peng Sun; Yingwen Dong; Sheng Bi; Rajesh Desai; Marissa Fallon Dockendorf; Nicholas A Kartsonis; Angela L Ngai; Susan Bradshaw; Julie A Stone
Journal:  Antimicrob Agents Chemother       Date:  2011-02-07       Impact factor: 5.191

6.  Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation.

Authors:  Isabel Spriet; Pieter Annaert; Philippe Meersseman; Greet Hermans; Wouter Meersseman; Rene Verbesselt; Ludo Willems
Journal:  J Antimicrob Chemother       Date:  2009-02-13       Impact factor: 5.790

7.  Determinants of drug absorption in different ECMO circuits.

Authors:  E D Wildschut; M J Ahsman; K Allegaert; R A A Mathot; D Tibboel
Journal:  Intensive Care Med       Date:  2010-09-23       Impact factor: 17.440

8.  Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.

Authors:  Joseph A Carcillo; Lesley Doughty; Danny Kofos; Reginald F Frye; Sandra S Kaplan; Howell Sasser; Gilbert J Burckart
Journal:  Intensive Care Med       Date:  2003-04-16       Impact factor: 17.440

9.  Pharmacokinetics and safety of caspofungin in older infants and toddlers.

Authors:  Michael Neely; Hasan S Jafri; Nita Seibel; Katherine Knapp; Peter C Adamson; Susan K Bradshaw; Kim M Strohmaier; Peng Sun; Sheng Bi; Marissa Fallon Dockendorf; Julie A Stone; Nicholas A Kartsonis
Journal:  Antimicrob Agents Chemother       Date:  2008-12-29       Impact factor: 5.191

10.  Effect of fluid loading during hypovolaemic shock on caspofungin pharmacokinetic parameters in pig.

Authors:  Antoine Roch; Christian Woloch; Dorothée Blayac; Caroline Solas; Sylvie Quaranta; Vincent Mardelle; Matthias Castanier; Laurent Papazian; Emmanuelle Sampol-Manos
Journal:  Crit Care       Date:  2011-09-20       Impact factor: 9.097
  10 in total
  3 in total

Review 1.  Drugs pharmacokinetics during veno-venous extracorporeal membrane oxygenation in pediatrics.

Authors:  Matteo Di Nardo; Enno Diederick Wildschut
Journal:  J Thorac Dis       Date:  2018-03       Impact factor: 2.895

Review 2.  Pharmacokinetics and Dosing of Anti-infective Drugs in Patients on Extracorporeal Membrane Oxygenation: A Review of the Current Literature.

Authors:  Jennifer Sherwin; Travis Heath; Kevin Watt
Journal:  Clin Ther       Date:  2016-08-21       Impact factor: 3.393

3.  Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review.

Authors:  Natalia Sutiman; Janine Cynthia Koh; Kevin Watt; Christoph Hornik; Beverly Murphy; Yoke Hwee Chan; Jan Hau Lee
Journal:  Front Pediatr       Date:  2020-06-26       Impact factor: 3.418
  3 in total

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