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Literature DB >> 24430449

Influence of Acanthamoeba genotype on clinical course and outcomes for patients with Acanthamoeba keratitis in Spain.

Francisco Arnalich-Montiel¹, Blanca Lumbreras-Fernández, Carmen M Martín-Navarro, Basilio Valladares, Rogelio Lopez-Velez, Rafael Morcillo-Laiz, Jacob Lorenzo-Morales.

Abstract

Genotype T4 is by far the most frequent genotype of Acanthamoeba keratitis (AK) and therefore has been considered the most virulent. This study included 14 cases of AK of genotype T4 and three cases of non-T4 genotype. We found that cases of non-T4 genotype had a worse response to medical therapy, greater need for surgical intervention, greater risk of extracorneal involvement, and remarkably poorer final visual outcome than those of T4 genotype, suggesting an association between Acanthamoeba virulence and genotype that requires additional case investigation.

Entities: Disease Species

Mesh：

Year: 2014 PMID： 24430449 PMCID： PMC3993498 DOI： 10.1128/JCM.00031-14

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

27 in total

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Journal: Cornea Date: 2010-09 Impact factor: 2.651

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Journal: Cornea Date: 2011-04 Impact factor: 2.651

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Journal: Am J Ophthalmol Date: 2009-08-05 Impact factor: 5.258

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Journal: Scand J Infect Dis Date: 2010-10

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Authors: Jacob Lorenzo-Morales; Rafael Morcillo-Laiz; Carmen Ma Martín-Navarro; Rogelio López-Vélez; Atteneri López-Arencibia; Francisco Arnalich-Montiel; Sutherland K Maciver; Basilio Valladares; Enrique Martínez-Carretero
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Journal: J Clin Microbiol Date: 2010-10-13 Impact factor: 5.948

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Journal: Exp Parasitol Date: 2009-10-24 Impact factor: 2.011

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Authors: T Martín-Pérez; T Lozano-Cruz; A Criado-Fornelio; P Ortega; R Gómez; F J de la Mata; J Pérez-Serrano
Journal: Parasitol Res Date: 2019-05-08 Impact factor: 2.289

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Authors: Derya Dirim Erdogan; Mehmet Aykur; Nur Selvi Gunel; Melis Palamar; Ozlem Barut Selver; Buket Ozel; Ayse Yagci; Cumhur Gunduz; Hande Dagci
Journal: Acta Parasitol Date: 2022-07-21 Impact factor: 1.534

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Journal: Parasitol Res Date: 2018-01-17 Impact factor: 2.289

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Journal: Parasitol Res Date: 2015-11-19 Impact factor: 2.289

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Authors: Dennis Back Holmgaard; Celine Barnadas; Seyed Hossein Mirbarati; Lee O'Brien Andersen; Henrik Vedel Nielsen; Christen Rune Stensvold
Journal: J Clin Microbiol Date: 2021-01-21 Impact factor: 5.948

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Authors: Thiago Dos Santos Gomes; Angela Magnet; Fernando Izquierdo; Lucianna Vaccaro; Fernando Redondo; Sara Bueno; Maria Luisa Sánchez; Santiago Angulo; Soledad Fenoy; Carolina Hurtado; Carmen Del Aguila
Journal: PLoS One Date: 2016-04-22 Impact factor: 3.240