Literature DB >> 24428577

A global assessment of stem cell engineering.

Jeanne F Loring1, Todd C McDevitt, Sean P Palecek, David V Schaffer, Peter W Zandstra, Robert M Nerem.   

Abstract

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic-industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms.

Entities:  

Mesh:

Year:  2014        PMID: 24428577      PMCID: PMC4195431          DOI: 10.1089/ten.TEA.2013.0468

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN: 1937-3341            Impact factor:   3.845


  68 in total

1.  Patterning osteogenesis by inducible gene expression in microfluidic culture systems.

Authors:  Yue Zhang; Zulma Gazit; Gadi Pelled; Dan Gazit; Gordana Vunjak-Novakovic
Journal:  Integr Biol (Camb)       Date:  2010-10-05       Impact factor: 2.192

2.  Agitation can induce differentiation of human pluripotent stem cells in microcarrier cultures.

Authors:  Hau Wan Leung; Allen Chen; Andre B H Choo; Shaul Reuveny; Steve K W Oh
Journal:  Tissue Eng Part C Methods       Date:  2010-11-04       Impact factor: 3.056

3.  Scalable platform for human embryonic stem cell differentiation to cardiomyocytes in suspended microcarrier cultures.

Authors:  Marti Lecina; Sherwin Ting; Andre Choo; Shaul Reuveny; Steve Oh
Journal:  Tissue Eng Part C Methods       Date:  2010-08-28       Impact factor: 3.056

Review 4.  MicroRNAs in embryonic stem cell function and fate.

Authors:  Gustavo Tiscornia; Juan Carlos Izpisúa Belmonte
Journal:  Genes Dev       Date:  2010-12-15       Impact factor: 11.361

5.  Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction.

Authors:  Yi-Chin Toh; Joel Voldman
Journal:  FASEB J       Date:  2010-12-23       Impact factor: 5.191

Review 6.  Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues.

Authors:  Albert J Keung; Sanjay Kumar; David V Schaffer
Journal:  Annu Rev Cell Dev Biol       Date:  2010       Impact factor: 13.827

7.  Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation.

Authors:  Andrés M Bratt-Leal; Richard L Carpenedo; Mark D Ungrin; Peter W Zandstra; Todd C McDevitt
Journal:  Biomaterials       Date:  2010-09-22       Impact factor: 12.479

8.  Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.

Authors:  Shannon L Stott; Chia-Hsien Hsu; Dina I Tsukrov; Min Yu; David T Miyamoto; Belinda A Waltman; S Michael Rothenberg; Ajay M Shah; Malgorzata E Smas; George K Korir; Frederick P Floyd; Anna J Gilman; Jenna B Lord; Daniel Winokur; Simeon Springer; Daniel Irimia; Sunitha Nagrath; Lecia V Sequist; Richard J Lee; Kurt J Isselbacher; Shyamala Maheswaran; Daniel A Haber; Mehmet Toner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-07       Impact factor: 11.205

9.  A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.

Authors:  Peter Buske; Jörg Galle; Nick Barker; Gabriela Aust; Hans Clevers; Markus Loeffler
Journal:  PLoS Comput Biol       Date:  2011-01-06       Impact factor: 4.475

10.  Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions.

Authors:  Farhan Chowdhury; Yanzhen Li; Yeh-Chuin Poh; Tamaki Yokohama-Tamaki; Ning Wang; Tetsuya S Tanaka
Journal:  PLoS One       Date:  2010-12-13       Impact factor: 3.240

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  2 in total

1.  Stem cell engineering.

Authors:  Robert M Nerem
Journal:  Tissue Eng Part A       Date:  2014-02-14       Impact factor: 3.845

2.  Pressuromodulation at the cell membrane as the basis for small molecule hormone and peptide regulation of cellular and nuclear function.

Authors:  Hemant Sarin
Journal:  J Transl Med       Date:  2015-11-26       Impact factor: 5.531

  2 in total

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