Literature DB >> 24426241

Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model?

Hanaa H Ahmed1, Selim F Estefan1, Ehab M Mohamd2, Abd El-Razik H Farrag3, Rania S Salah1.   

Abstract

This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl3 to induce AD and AD-induced rats treated with melatonin. Hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

Entities:  

Keywords:  Alzheimer’s disease; Anti-amyloidogenesis; Melatonin; Neurogenesis; Rats

Year:  2012        PMID： 24426241      PMCID： PMC3783909          DOI： 10.1007/s12291-012-0284-x

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  50 in total

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7.  Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer's disease after chronic exposure to aluminum.

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Review 8.  Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity.

Authors:  M Weinstock; S Shoham
Journal:  J Neural Transm (Vienna)       Date:  2003-12-12       Impact factor: 3.575

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10.  Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain.

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Journal:  Toxicology       Date:  2009-05-21       Impact factor: 4.221
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  3 in total

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2.  Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer's Disease.

Authors:  Samah Labban; Fahad S Alshehri; Maher Kurdi; Yasser Alatawi; Badrah S Alghamdi
Journal:  Degener Neurol Neuromuscul Dis       Date:  2021-05-06

3.  The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats.

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  3 in total

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