Literature DB >> 16217124

Measurement of melatonin and its metabolites: importance for the evaluation of their biological roles.

Glaucia R Martinez1, Eduardo A Almeida, Clécio F Klitzke, Janice Onuki, Fernanda M Prado, Marisa H G Medeiros, Paolo Di Mascio.   

Abstract

Many physiologic changes related to light-dark cycles and antioxidant effects have been related to melatonin (N-acetyl-5-methoxytryptamine) and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK). In this review, we discuss some methodologies, in particular, those employing high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) assays to quantitatively determine melatonin, AFMK, and AMK. These approaches offer a highly specific and an accurate quantification of melatonin and its metabolites. These characteristics are essential to point out correctly the biological effects of these compounds in physiological and pathological conditions.

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Year:  2005        PMID： 16217124     DOI： 10.1385/endo:27:2:111

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  40 in total

Review 1.  Separation and assay methods for melatonin and its precursors.

Authors:  T Harumi; S Matsushima
Journal:  J Chromatogr B Biomed Sci Appl       Date:  2000-09-29

2.  Fluorometric determination of indole derivatives.

Authors:  F P Miller; R P Maickel
Journal:  Life Sci I       Date:  1970-07-01

3.  N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant.

Authors:  D X Tan; L C Manchester; S Burkhardt; R M Sainz; J C Mayo; R Kohen; E Shohami; Y S Huo; R Hardeland; R J Reiter
Journal:  FASEB J       Date:  2001-08-17       Impact factor: 5.191

4.  Cytotoxicity and mutagenesis induced by singlet oxygen in wild type and DNA repair deficient Escherichia coli strains.

Authors:  Ana Karina Dias Cavalcante; Glaucia Regina Martinez; Paolo Di Mascio; Carlos Frederico Martins Menck; Lucymara Fassarella Agnez-Lima
Journal:  DNA Repair (Amst)       Date:  2002-12-05

5.  Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): a melatonin oxidative metabolite.

Authors:  Catherine Harthé; Danièle Claudy; Henri Déchaud; Berthe Vivien-Roels; Paul Pévet; Bruno Claustrat
Journal:  Life Sci       Date:  2003-08-08       Impact factor: 5.037

6.  Synthesis of internal labeled standards of melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine for their quantification using an on-line liquid chromatography-electrospray tandem mass spectrometry system.

Authors:  Eduardo A Almeida; Clécio F Klitzke; Glaucia R Martinez; Marisa H G Medeiros; Paolo Di Mascio
Journal:  J Pineal Res       Date:  2004-01       Impact factor: 13.007

7.  Oxidation of melatonin by singlet molecular oxygen (O2(1deltag)) produces N1-acetyl-N2-formyl-5-methoxykynurenine.

Authors:  Eduardo A de Almeida; Glaucia R Martinez; Clécio F Klitzke; Marisa H G de Medeiros; Paolo Di Mascio
Journal:  J Pineal Res       Date:  2003-09       Impact factor: 13.007

Review 8.  Melatonin: a coordinating signal for mammalian reproduction?

Authors:  L Tamarkin; C J Baird; O F Almeida
Journal:  Science       Date:  1985-02-15       Impact factor: 47.728

Review 9.  Oxidative and alkylating damage in DNA.

Authors:  Glaucia R Martinez; Ana Paula M Loureiro; Sabrina A Marques; Sayuri Miyamoto; Lydia F Yamaguchi; Janice Onuki; Eduardo A Almeida; Camila C M Garcia; Lívea F Barbosa; Marisa H G Medeiros; Paolo Di Mascio
Journal:  Mutat Res       Date:  2003-11       Impact factor: 2.433

10.  Determination of melatonin in biological fluids in the presence of the melatonin agonist S 20098: comparison of immunological techniques and GC-MS methods.

Authors:  G Simonin; L Bru; E Lelièvre; J P Jeanniot; N Bromet; B Walther; C Boursier-Neyret
Journal:  J Pharm Biomed Anal       Date:  1999-11       Impact factor: 3.935
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  6 in total

1.  Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model?

Authors:  Hanaa H Ahmed; Selim F Estefan; Ehab M Mohamd; Abd El-Razik H Farrag; Rania S Salah
Journal:  Indian J Clin Biochem       Date:  2012-12-22

2.  Antiinflammatory activity of melatonin in central nervous system.

Authors:  Emanuela Esposito; Salvatore Cuzzocrea
Journal:  Curr Neuropharmacol       Date:  2010-09       Impact factor: 7.363

Review 3.  Ionizing Radiation as a Source of Oxidative Stress-The Protective Role of Melatonin and Vitamin D.

Authors:  Jarosław Nuszkiewicz; Alina Woźniak; Karolina Szewczyk-Golec
Journal:  Int J Mol Sci       Date:  2020-08-13       Impact factor: 5.923

Review 4.  Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care.

Authors:  Anna Tarocco; Natascia Caroccia; Giampaolo Morciano; Mariusz R Wieckowski; Gina Ancora; Giampaolo Garani; Paolo Pinton
Journal:  Cell Death Dis       Date:  2019-04-08       Impact factor: 8.469

Review 5.  Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance.

Authors:  Doris Loh; Russel J Reiter
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411

6.  Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors.

Authors:  Gloria Somalo-Barranco; Carme Serra; David Lyons; Hugh D Piggins; Ralf Jockers; Amadeu Llebaria
Journal:  J Med Chem       Date:  2022-08-05       Impact factor: 8.039
  6 in total

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