Sung Mok Kim1, Sung-A Chang, Wonseon Shin, Yeon Hyeon Choe. 1. From the *Department of Radiology, †Cardiovascular Imaging Center, and ‡Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; and §Department of Radiology, College of Medicine, Kangwon National University, Chuncheon-Si, Gangwon-Do, Korea.
Abstract
OBJECTIVES: This study aimed to assess the diagnostic performance of adenosine-stress dual-energy myocardial computed tomography perfusion (DECTP) imaging using 128-slice dual-source computed tomography (CT) for the detection of myocardial perfusion defects in comparison with stress-perfusion magnetic resonance imaging (MRI). METHODS: This prospective study included 50 patients (mean age, 66 [9] years; 64% men) with suspected coronary artery disease who underwent adenosine-stress DECTP using 128-slice dual-source CT as well as adenosine-stress cardiac MRI using a 1.5-T scanner. Estimates of diagnostic accuracy in detecting myocardial perfusion defects were calculatedand compared with those of cardiac MRI. RESULTS: The estimates of diagnostic accuracy in detecting myocardial perfusion defects using DECTP were as follows: sensitivity, 77% (95% confidence interval [CI], 67%-87%); specificity, 94% (95% CI, 92%-95%); positive predictive value, 53% (95% CI, 44%-63%); and negative predictive value, 98% (95% CI, 97%-99%). The results of DECTP imaging were positively correlated with those of cardiac MRI (r = 0.602, P < 0.001). Mean effective radiation doses for stress DECTP imaging and rest coronary CTA were 6.5 (2.2) and 4.9 (1.7) mSv, respectively. CONCLUSIONS: Adenosine-stress DECTP imaging enables detection of myocardial ischemia. However, further technical developments are necessary to reduce artifacts and improve the sensitivity of DECTP.
OBJECTIVES: This study aimed to assess the diagnostic performance of adenosine-stress dual-energy myocardial computed tomography perfusion (DECTP) imaging using 128-slice dual-source computed tomography (CT) for the detection of myocardial perfusion defects in comparison with stress-perfusion magnetic resonance imaging (MRI). METHODS: This prospective study included 50 patients (mean age, 66 [9] years; 64% men) with suspected coronary artery disease who underwent adenosine-stress DECTP using 128-slice dual-source CT as well as adenosine-stress cardiac MRI using a 1.5-T scanner. Estimates of diagnostic accuracy in detecting myocardial perfusion defects were calculatedand compared with those of cardiac MRI. RESULTS: The estimates of diagnostic accuracy in detecting myocardial perfusion defects using DECTP were as follows: sensitivity, 77% (95% confidence interval [CI], 67%-87%); specificity, 94% (95% CI, 92%-95%); positive predictive value, 53% (95% CI, 44%-63%); and negative predictive value, 98% (95% CI, 97%-99%). The results of DECTP imaging were positively correlated with those of cardiac MRI (r = 0.602, P < 0.001). Mean effective radiation doses for stress DECTP imaging and rest coronary CTA were 6.5 (2.2) and 4.9 (1.7) mSv, respectively. CONCLUSIONS:Adenosine-stress DECTP imaging enables detection of myocardial ischemia. However, further technical developments are necessary to reduce artifacts and improve the sensitivity of DECTP.
Authors: Francesco Secchi; Marco Alì; Elena Faggiano; Paola Maria Cannaò; Marco Fedele; Silvia Tresoldi; Giovanni Di Leo; Ferdinando Auricchio; Francesco Sardanelli Journal: Eur Heart J Suppl Date: 2016-04-29 Impact factor: 1.803
Authors: Filippo Cademartiri; Sara Seitun; Alberto Clemente; Ludovico La Grutta; Patrizia Toia; Giuseppe Runza; Massimo Midiri; Erica Maffei Journal: Cardiovasc Diagn Ther Date: 2017-04
Authors: Giovanni Di Leo; Erica Fisci; Francesco Secchi; Marco Alì; Federico Ambrogi; Luca Maria Sconfienza; Francesco Sardanelli Journal: Eur Radiol Date: 2015-12-11 Impact factor: 5.315
Authors: Jagat Narula; Y Chandrashekhar; Amir Ahmadi; Suhny Abbara; Daniel S Berman; Ron Blankstein; Jonathon Leipsic; David Newby; Edward D Nicol; Koen Nieman; Leslee Shaw; Todd C Villines; Michelle Williams; Harvey S Hecht Journal: J Cardiovasc Comput Tomogr Date: 2020-11-20