Literature DB >> 24424135

1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation.

Raghu Raj1, Jiri Gut2, Philip J Rosenthal2, Vipan Kumar3.   

Abstract

A series of 1H-1,2,3-triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates have been synthesized and evaluated for their antimalarial activity against chloroquine-resistant W2 strain of Plasmodium falciparum. The most potent of the test compound with an optimum combination of 3-hydroxy-indole ring and a n-butyl linker displayed an IC50 value of 69 nM.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  1H-1,2,3-Triazole; 3-Hydroxy-indole-2-one; 7-Chloroquinoline; Antimalarial activity; Isatin

Mesh：

Substances：

Year:  2014        PMID： 24424135     DOI： 10.1016/j.bmcl.2013.12.109

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs).

Authors:  Shefali Chowdhary; Amandeep Arora; Vipan Kumar
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-27

Review 2.  Exploration of the Detailed Structure-Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors.

Authors:  Sunil Kumar; Aathira Sujathan Nair; Mohamed A Abdelgawad; Bijo Mathew
Journal:  ACS Omega       Date:  2022-05-05

3.  Microwave-assisted synthesis, antioxidant and antimicrobial evaluation of 2-indolinone-based bis-1,2,3-triazole derivatives.

Authors:  Dongamanti Ashok; Srinivas Gundu; Vikas Kumar Aamate; Mohan Gandhi Devulapally
Journal:  Mol Divers       Date:  2017-11-07       Impact factor: 2.943

4.  β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation.

Authors:  Jiri Gut; Philip J Rosenthal; Vipan Kumar
Journal:  Eur J Med Chem       Date:  2014-07-21       Impact factor: 6.514

5.  Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides.

Authors:  Waldemar Schilling; Yu Zhang; Daniel Riemer; Shoubhik Das
Journal:  Chemistry       Date:  2019-12-05       Impact factor: 5.236
  5 in total

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