Ane Garmendia Madariaga1, Silvia Santos Palacios, Francisco Guillén-Grima, Juan C Galofré. 1. Departments of Endocrinology and Nutrition (A.G.M., S.S.P., J.C.G.) and Preventive Medicine (F.G.-G.), Clínica Universidad de Navarra, University of Navarra, 31008 Pamplona, Spain; and Department of Health Sciences (F.G.-G.), Public University of Navarra, 31008 Pamplona, Spain.
Abstract
CONTEXT: Thyroid dysfunction is one of the leading endocrine disorders. Previous data show that about half of the population with thyroid dysfunction remains undiagnosed. OBJECTIVE: Our objective was to estimate epidemiologic data on thyroid dysfunction in Europe. DATA SOURCES: PubMed, EMBASE, and SCOPUS databases were searched to identify studies that evaluated the prevalence and/or incidence of thyroid dysfunction in Europe published between 1975 and 2012. STUDY SELECTION: Of the 541 identified abstracts examined, 178 were considered for evaluation and 17 were included. Studies were excluded if they included participants with an underlying disease or were limited by age or gender. DATA EXTRACTION: Results were grouped into 3 categories: 1) prevalence of undiagnosed thyroid dysfunction, 2) prevalence of thyroid dysfunction, and 3) incidence of thyroid dysfunction. Extraction was conducted independently by 2 investigators. DATA SYNTHESIS: An empirical Bayesian random-effects model was used. The prevalence of undiagnosed thyroid dysfunction was assessed in 7 studies with a mean result of 6.71% (95% credibility interval, 6.49%-6.93%): 4.94% (4.75%-5.13%) and 1.72% (1.66%-1.88%) for undiagnosed hypothyroidism and hyperthyroidism, respectively. The prevalence of both previously diagnosed and undiagnosed thyroid dysfunction was assessed in 9 studies with a mean result of 3.82% (3.77%-3.86%): 3.05% (3.01%-3.09%) and 0.75% (0.73%-0.77%) for hypothyroidism and hyperthyroidism, respectively. The incidence rate of thyroid dysfunction was assessed in 7 studies with a mean result of 259.12 (254.39-263.9) per 100 000 per year: 226.2 (222.26-230.17) and 51 (49.23-52.88) per 100 000 per year for hypothyroidism and hyperthyroidism, respectively. CONCLUSION: This meta-analysis provides extensive data on the prevalence and incidence of thyroid dysfunction in Europe.
CONTEXT: Thyroid dysfunction is one of the leading endocrine disorders. Previous data show that about half of the population with thyroid dysfunction remains undiagnosed. OBJECTIVE: Our objective was to estimate epidemiologic data on thyroid dysfunction in Europe. DATA SOURCES: PubMed, EMBASE, and SCOPUS databases were searched to identify studies that evaluated the prevalence and/or incidence of thyroid dysfunction in Europe published between 1975 and 2012. STUDY SELECTION: Of the 541 identified abstracts examined, 178 were considered for evaluation and 17 were included. Studies were excluded if they included participants with an underlying disease or were limited by age or gender. DATA EXTRACTION: Results were grouped into 3 categories: 1) prevalence of undiagnosed thyroid dysfunction, 2) prevalence of thyroid dysfunction, and 3) incidence of thyroid dysfunction. Extraction was conducted independently by 2 investigators. DATA SYNTHESIS: An empirical Bayesian random-effects model was used. The prevalence of undiagnosed thyroid dysfunction was assessed in 7 studies with a mean result of 6.71% (95% credibility interval, 6.49%-6.93%): 4.94% (4.75%-5.13%) and 1.72% (1.66%-1.88%) for undiagnosed hypothyroidism and hyperthyroidism, respectively. The prevalence of both previously diagnosed and undiagnosed thyroid dysfunction was assessed in 9 studies with a mean result of 3.82% (3.77%-3.86%): 3.05% (3.01%-3.09%) and 0.75% (0.73%-0.77%) for hypothyroidism and hyperthyroidism, respectively. The incidence rate of thyroid dysfunction was assessed in 7 studies with a mean result of 259.12 (254.39-263.9) per 100 000 per year: 226.2 (222.26-230.17) and 51 (49.23-52.88) per 100 000 per year for hypothyroidism and hyperthyroidism, respectively. CONCLUSION: This meta-analysis provides extensive data on the prevalence and incidence of thyroid dysfunction in Europe.
Authors: Livia López-Noriega; Nadia Cobo-Vuilleumier; Álvaro Jesús Narbona-Pérez; Juan Luis Araujo-Garrido; Petra Isabel Lorenzo; José Manuel Mellado-Gil; José Carlos Moreno; Benoit R Gauthier; Alejandro Martín-Montalvo Journal: Br J Pharmacol Date: 2017-09-20 Impact factor: 8.739
Authors: Giovanni Defazio; M Esposito; G Abbruzzese; C L Scaglione; G Fabbrini; G Ferrazzano; S Peluso; R Pellicciari; A F Gigante; G Cossu; R Arca; L Avanzino; F Bono; M R Mazza; L Bertolasi; R Bacchin; R Eleopra; C Lettieri; F Morgante; M C Altavista; L Polidori; R Liguori; S Misceo; G Squintani; M Tinazzi; R Ceravolo; E Unti; L Magistrelli; M Coletti Moja; N Modugno; M Petracca; N Tambasco; M S Cotelli; M Aguggia; A Pisani; M Romano; M Zibetti; A R Bentivoglio; A Albanese; P Girlanda; A Berardelli Journal: Neurol Sci Date: 2017-02-18 Impact factor: 3.307