Literature DB >> 29654845

Immune senescence, epigenetics and autoimmunity.

Donna Ray1, Raymond Yung2.   

Abstract

Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation ("inflammaging") and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and autoimmunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Autoimmunity; Epigenetics; Immune senescence; Inflammation

Mesh：

Year:  2018        PMID： 29654845      PMCID： PMC6548177          DOI： 10.1016/j.clim.2018.04.002

Source DB:  PubMed          Journal:  Clin Immunol        ISSN： 1521-6616            Impact factor:   3.969


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