Literature DB >> 24418759

MLKL regulates necrotic plasma membrane permeabilization.

Lorenzo Galluzzi1, Oliver Kepp2, Guido Kroemer3.   

Abstract

Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma membrane and compromise its ability to preserve ionic homeostasis.

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Year:  2014        PMID： 24418759      PMCID： PMC3915909          DOI： 10.1038/cr.2014.8

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  11 in total

1.  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.

Authors:  Alexei Degterev; Zhihong Huang; Michael Boyce; Yaqiao Li; Prakash Jagtap; Noboru Mizushima; Gregory D Cuny; Timothy J Mitchison; Michael A Moskowitz; Junying Yuan
Journal:  Nat Chem Biol       Date:  2005-05-29       Impact factor: 15.040

2.  Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.

Authors:  Liming Sun; Huayi Wang; Zhigao Wang; Sudan He; She Chen; Daohong Liao; Lai Wang; Jiacong Yan; Weilong Liu; Xiaoguang Lei; Xiaodong Wang
Journal:  Cell       Date:  2012-01-20       Impact factor: 41.582

3.  Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.

Authors:  Zhenyu Cai; Siriporn Jitkaew; Jie Zhao; Hsueh-Cheng Chiang; Swati Choksi; Jie Liu; Yvona Ward; Ling-Gang Wu; Zheng-Gang Liu
Journal:  Nat Cell Biol       Date:  2013-12-08       Impact factor: 28.824

Review 4.  Molecular mechanisms of necroptosis: an ordered cellular explosion.

Authors:  Peter Vandenabeele; Lorenzo Galluzzi; Tom Vanden Berghe; Guido Kroemer
Journal:  Nat Rev Mol Cell Biol       Date:  2010-09-08       Impact factor: 94.444

Review 5.  Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012.

Authors:  L Galluzzi; I Vitale; J M Abrams; E S Alnemri; E H Baehrecke; M V Blagosklonny; T M Dawson; V L Dawson; W S El-Deiry; S Fulda; E Gottlieb; D R Green; M O Hengartner; O Kepp; R A Knight; S Kumar; S A Lipton; X Lu; F Madeo; W Malorni; P Mehlen; G Nuñez; M E Peter; M Piacentini; D C Rubinsztein; Y Shi; H-U Simon; P Vandenabeele; E White; J Yuan; B Zhivotovsky; G Melino; G Kroemer
Journal:  Cell Death Differ       Date:  2011-07-15       Impact factor: 15.828

6.  Necroptosis: a specialized pathway of programmed necrosis.

Authors:  Lorenzo Galluzzi; Guido Kroemer
Journal:  Cell       Date:  2008-12-26       Impact factor: 41.582

7.  Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.

Authors:  Andrew Oberst; Christopher P Dillon; Ricardo Weinlich; Laura L McCormick; Patrick Fitzgerald; Cristina Pop; Razq Hakem; Guy S Salvesen; Douglas R Green
Journal:  Nature       Date:  2011-03-02       Impact factor: 49.962

Review 8.  Many stimuli pull the necrotic trigger, an overview.

Authors:  N Vanlangenakker; T Vanden Berghe; P Vandenabeele
Journal:  Cell Death Differ       Date:  2011-11-11       Impact factor: 15.828

9.  Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis.

Authors:  Jianfeng Wu; Zhe Huang; Junming Ren; Zhirong Zhang; Peng He; Yangxin Li; Jianhui Ma; Wanze Chen; Yingying Zhang; Xiaojuan Zhou; Zhentao Yang; Su-Qin Wu; Lanfen Chen; Jiahuai Han
Journal:  Cell Res       Date:  2013-07-09       Impact factor: 25.617

10.  Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death.

Authors:  Xin Chen; Wenjuan Li; Junming Ren; Deli Huang; Wan-Ting He; Yunlong Song; Chao Yang; Wanyun Li; Xinru Zheng; Pengda Chen; Jiahuai Han
Journal:  Cell Res       Date:  2013-12-24       Impact factor: 25.617
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  32 in total

1.  Polyphyllin D, a steroidal saponin in Paris polyphylla, induces apoptosis and necroptosis cell death of neuroblastoma cells.

Authors:  Shunsuke Watanabe; Tatuya Suzuki; Fujio Hara; Toshihiro Yasui; Naoko Uga; Atuki Naoe
Journal:  Pediatr Surg Int       Date:  2017-03-04       Impact factor: 1.827

Review 2.  Developmental checkpoints guarded by regulated necrosis.

Authors:  Christopher P Dillon; Bart Tummers; Katherine Baran; Douglas R Green
Journal:  Cell Mol Life Sci       Date:  2016-04-07       Impact factor: 9.261

3.  Milk makes lysosomes lethal.

Authors:  Shefali Krishna; Michael Overholtzer
Journal:  Nat Cell Biol       Date:  2014-11       Impact factor: 28.824

4.  Pro-necrotic molecules impact local immunosurveillance in human breast cancer.

Authors:  Gautier Stoll; Yuting Ma; Heng Yang; Oliver Kepp; Laurence Zitvogel; Guido Kroemer
Journal:  Oncoimmunology       Date:  2017-04-17       Impact factor: 8.110

5.  Viral RNA at Two Stages of Reovirus Infection Is Required for the Induction of Necroptosis.

Authors:  Angela K Berger; Bradley E Hiller; Deepti Thete; Anthony J Snyder; Encarnacion Perez; Jason W Upton; Pranav Danthi
Journal:  J Virol       Date:  2017-02-28       Impact factor: 5.103

6.  Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner.

Authors:  Zhai Ertao; Chen Jianhui; Wang Kang; Ye Zhijun; Wu Hui; Chen Chuangqi; Qin Changjiang; Chen Sile; He Yulong; Cai Shirong
Journal:  Tumour Biol       Date:  2016-07-29

7.  Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.

Authors:  Giovanni Quarato; Cliff S Guy; Christy R Grace; Fabien Llambi; Amanda Nourse; Diego A Rodriguez; Randall Wakefield; Sharon Frase; Tudor Moldoveanu; Douglas R Green
Journal:  Mol Cell       Date:  2016-02-04       Impact factor: 17.970

8.  Up-regulated Ectonucleotidases in Fas-Associated Death Domain Protein- and Receptor-Interacting Protein Kinase 1-Deficient Jurkat Leukemia Cells Counteract Extracellular ATP/AMP Accumulation via Pannexin-1 Channels during Chemotherapeutic Drug-Induced Apoptosis.

Authors:  Andrea M Boyd-Tressler; Graham S Lane; George R Dubyak
Journal:  Mol Pharmacol       Date:  2017-05-01       Impact factor: 4.436

9.  Impaired oxidative phosphorylation regulates necroptosis in human lung epithelial cells.

Authors:  Michael Jakun Koo; Kristen T Rooney; Mary E Choi; Stefan W Ryter; Augustine M K Choi; Jong-Seok Moon
Journal:  Biochem Biophys Res Commun       Date:  2015-07-14       Impact factor: 3.575

10.  TRAF2 is a biologically important necroptosis suppressor.

Authors:  S L Petersen; T T Chen; D A Lawrence; S A Marsters; F Gonzalvez; A Ashkenazi
Journal:  Cell Death Differ       Date:  2015-04-17       Impact factor: 15.828
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