Literature DB >> 25358350

Milk makes lysosomes lethal.

Shefali Krishna1, Michael Overholtzer1.   

Abstract

Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of cathepsin proteases.

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Year:  2014        PMID： 25358350     DOI： 10.1038/ncb3059

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.

Authors:  Alexei Degterev; Zhihong Huang; Michael Boyce; Yaqiao Li; Prakash Jagtap; Noboru Mizushima; Gregory D Cuny; Timothy J Mitchison; Michael A Moskowitz; Junying Yuan
Journal:  Nat Chem Biol       Date:  2005-05-29       Impact factor: 15.040

2.  Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.

Authors:  Yang Liu; Sanae Shoji-Kawata; Rhea M Sumpter; Yongjie Wei; Vanessa Ginet; Liying Zhang; Bruce Posner; Khoa A Tran; Douglas R Green; Ramnik J Xavier; Stanley Y Shaw; Peter G H Clarke; Julien Puyal; Beth Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-25       Impact factor: 11.205

3.  Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8.

Authors:  Rikinari Hanayama; Shigekazu Nagata
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-07       Impact factor: 11.205

4.  Stat3 controls lysosomal-mediated cell death in vivo.

Authors:  Peter A Kreuzaler; Anna D Staniszewska; Wenjing Li; Nader Omidvar; Blandine Kedjouar; James Turkson; Valeria Poli; Richard A Flavell; Richard W E Clarkson; Christine J Watson
Journal:  Nat Cell Biol       Date:  2011-02-20       Impact factor: 28.824

5.  Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis.

Authors:  Jean H Overmeyer; Aparna Kaul; Erin E Johnson; William A Maltese
Journal:  Mol Cancer Res       Date:  2008-06       Impact factor: 5.852

6.  Activation of autophagy during cell death requires the engulfment receptor Draper.

Authors:  Christina K McPhee; Mary A Logan; Marc R Freeman; Eric H Baehrecke
Journal:  Nature       Date:  2010-06-24       Impact factor: 49.962

7.  Cathepsin L plays an active role in involution of the mouse mammary gland.

Authors:  Michael A Burke; Dorothy Hutter; Rita P Reshamwala; Janice E Knepper
Journal:  Dev Dyn       Date:  2003-07       Impact factor: 3.780

Review 8.  The Stat3 paradox: a killer and an oncogene.

Authors:  Henrike K Resemann; Christine J Watson; Bethan Lloyd-Lewis
Journal:  Mol Cell Endocrinol       Date:  2013-07-01       Impact factor: 4.102

9.  Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.

Authors:  Cosimo Commisso; Shawn M Davidson; Rengin G Soydaner-Azeloglu; Seth J Parker; Jurre J Kamphorst; Sean Hackett; Elda Grabocka; Michel Nofal; Jeffrey A Drebin; Craig B Thompson; Joshua D Rabinowitz; Christian M Metallo; Matthew G Vander Heiden; Dafna Bar-Sagi
Journal:  Nature       Date:  2013-05-12       Impact factor: 49.962

10.  Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization.

Authors:  Timothy J Sargeant; Bethan Lloyd-Lewis; Henrike K Resemann; Antonio Ramos-Montoya; Jeremy Skepper; Christine J Watson
Journal:  Nat Cell Biol       Date:  2014-10-05       Impact factor: 28.824
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