BACKGROUND: Significant controversy exists in the literature regarding the role of pregnancy in the prognosis of breast cancer. We designed a matched case-case study, matching pregnancy-associated breast cancer (PABC) cases with breast cancer cases for stage, age, and year of diagnosis. PATIENTS AND METHODS: 39 consecutive cases of PABC were matched with 39 premenopausal cases of breast cancer. Univariate and multivariate survival analyses followed by adjustment for stage, grade, estrogen receptor status, and age at diagnosis, were performed. RESULTS: Regarding overall survival (OS), univariate analysis pointed to longer OS in non-PABC cases vs. PABC cases. Accordingly, a more advanced stage predicted shorter survival. In the multivariate analysis, the independent aggravating effect mediated by pregnancy persisted. Interestingly, a post hoc nested analysis within PABC cases indicated that the 3rd trimester pointed to shorter OS. The aforementioned results on OS were also replicated during the examination of relapse-free survival. CONCLUSION: Implementing a matched case-case design, the present study points to pregnancy as a poor prognostic factor for breast cancer.
BACKGROUND: Significant controversy exists in the literature regarding the role of pregnancy in the prognosis of breast cancer. We designed a matched case-case study, matching pregnancy-associated breast cancer (PABC) cases with breast cancer cases for stage, age, and year of diagnosis. PATIENTS AND METHODS: 39 consecutive cases of PABC were matched with 39 premenopausal cases of breast cancer. Univariate and multivariate survival analyses followed by adjustment for stage, grade, estrogen receptor status, and age at diagnosis, were performed. RESULTS: Regarding overall survival (OS), univariate analysis pointed to longer OS in non-PABC cases vs. PABC cases. Accordingly, a more advanced stage predicted shorter survival. In the multivariate analysis, the independent aggravating effect mediated by pregnancy persisted. Interestingly, a post hoc nested analysis within PABC cases indicated that the 3rd trimester pointed to shorter OS. The aforementioned results on OS were also replicated during the examination of relapse-free survival. CONCLUSION: Implementing a matched case-case design, the present study points to pregnancy as a poor prognostic factor for breast cancer.
Entities:
Keywords:
Breast cancer; Pregnancy; Prognosis; Survival
Authors: Michael J Halaska; George Pentheroudakis; Pavel Strnad; Hana Stankusova; Jiri Chod; Helena Robova; Lubos Petruzelka; Lukas Rob; Nicholas Pavlidis Journal: Breast J Date: 2009-06-13 Impact factor: 2.431
Authors: Beth M Beadle; Wendy A Woodward; Lavinia P Middleton; Welela Tereffe; Eric A Strom; Jennifer K Litton; Funda Meric-Bernstam; Richard L Theriault; Thomas A Buchholz; George H Perkins Journal: Cancer Date: 2009-03-15 Impact factor: 6.860
Authors: Sanah N Vohra; Andrea Walens; Alina M Hamilton; Mark E Sherman; Pepper Schedin; Hazel B Nichols; Katherine E Reeder-Hayes; Andrew F Olshan; Michael I Love; Melissa A Troester Journal: Cancer Epidemiol Biomarkers Prev Date: 2022-03-01 Impact factor: 4.090
Authors: Sanah N Vohra; Katherine E Reeder-Hayes; Hazel B Nichols; Marc A Emerson; Michael I Love; Andrew F Olshan; Melissa A Troester Journal: Breast Cancer Res Treat Date: 2022-01-10 Impact factor: 4.624