Chen Zhu1, Ji-Bao Xia1, Chuo Chen1. 1. Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038.
Abstract
We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension.
We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary n class="Chemical">amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension.
Authors: Valentin Köhler; Kevin R Bailey; Anass Znabet; James Raftery; Madeleine Helliwell; Nicholas J Turner Journal: Angew Chem Int Ed Engl Date: 2010-03-15 Impact factor: 15.336