Literature DB >> 2441387

Inhibitory action of transforming growth factor beta on endothelial cells.

G Müller, J Behrens, U Nussbaumer, P Böhlen, W Birchmeier.   

Abstract

In the present study, we show that transforming growth factor beta (TGF-beta) strongly inhibits fibroblast growth factor-induced proliferation and motility of bovine endothelial cells in tissue culture. TGF-beta also prevents the phorbol ester-induced invasion of capillary endothelial cells into collagen matrices--i.e., blocks angiogenesis in vitro. TGF-beta promotes the incorporation of fibronectin into the extracellular matrix of endothelial cells and stimulates the secretion of other proteins--mainly of 55- and 180-kDa components. We show furthermore that endothelial cells express TGF-beta receptors similar in size to those of other tissue culture cell lines: a 280-kDa complex is present in subconfluent cells, and 85- and 72-kDa protein bands are seen in confluent cells. The various effects of TGF-beta on endothelial cells suggest that these cells are an important target of TGF-beta during wound healing and angiogenesis.

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Year:  1987        PMID： 2441387      PMCID： PMC298910          DOI： 10.1073/pnas.84.16.5600

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  51 in total

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Authors:  J E de Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

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Authors:  R A Ignotz; J Massagué
Journal:  J Biol Chem       Date:  1986-03-25       Impact factor: 5.157

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

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Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

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5.  Similarities and differences between the fibronectins of normal and transformed hamster cells.

Authors:  D D Wagner; R Ivatt; A T Destree; R O Hynes
Journal:  J Biol Chem       Date:  1981-11-25       Impact factor: 5.157

6.  Corrugated attachment membrane in WI-38 fibroblasts: alternating fibronectin fibers and actin-containing focal contacts.

Authors:  C Birchmeier; T E Kreis; H M Eppenberger; K H Winterhalter; W Birchmeier
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

7.  Role of attachment factors and attractants in fibroblast chemotaxis.

Authors:  V Gauss-Müller; H K Kleinman; G R Martin; E Schiffmann
Journal:  J Lab Clin Med       Date:  1980-12

8.  Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo.

Authors:  M B Sporn; A B Roberts; J H Shull; J M Smith; J M Ward; J Sodek
Journal:  Science       Date:  1983-03-18       Impact factor: 47.728

9.  New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

Authors:  A B Roberts; M A Anzano; L C Lamb; J M Smith; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

10.  The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.

Authors:  J R Couchman; D A Rees
Journal:  J Cell Sci       Date:  1979-10       Impact factor: 5.285
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  54 in total

1.  Isolation and characterization of a macrophage-derived heparin-binding growth factor.

Authors:  G Besner; S Higashiyama; M Klagsbrun
Journal:  Cell Regul       Date:  1990-10

2.  Galectin-3 induces endothelial cell morphogenesis and angiogenesis.

Authors:  P Nangia-Makker; Y Honjo; R Sarvis; S Akahani; V Hogan; K J Pienta; A Raz
Journal:  Am J Pathol       Date:  2000-03       Impact factor: 4.307

3.  Transforming growth factor-beta complexes with thrombospondin.

Authors:  J E Murphy-Ullrich; S Schultz-Cherry; M Höök
Journal:  Mol Biol Cell       Date:  1992-02       Impact factor: 4.138

4.  Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance.

Authors:  O Kocher; S P Kennedy; J A Madri
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

5.  Angiogenesis in rheumatoid arthritis: implications for future therapeutic strategies.

Authors:  E M Paleolog; R A Fava
Journal:  Springer Semin Immunopathol       Date:  1998

6.  Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation.

Authors:  Nicolas C Rivron; Christian C Raiss; Jun Liu; Anandkumar Nandakumar; Carsten Sticht; Norbert Gretz; Roman Truckenmüller; Jeroen Rouwkema; Clemens A van Blitterswijk
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-02       Impact factor: 11.205

7.  Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.

Authors:  S E Lynch; R B Colvin; H N Antoniades
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

8.  Scatter factor induces blood vessel formation in vivo.

Authors:  D S Grant; H K Kleinman; I D Goldberg; M M Bhargava; B J Nickoloff; J L Kinsella; P Polverini; E M Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

9.  A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.

Authors:  S K Gupta; T Hassel; J P Singh
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

10.  Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

Authors:  J R Merwin; W Newman; L D Beall; A Tucker; J Madri
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307
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