Somlak Chuengsamarn1, Suthee Rattanamongkolgul2, Siwanon Jirawatnotai3. 1. Division of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand. Electronic address: somlukc@swu.ac.th. 2. Department of Preventive and Social Medicine, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand. 3. Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Abstract
AIMS: To investigate an association between serum uric acid/microalbuminuria and chronic micro/macro-vascular complications in type 2 diabetic patients. METHODS: This cross-sectional study enrolled 608 patients with type 2 diabetes. All subjects were examined and basic information on health of the subjects was recorded for inclusion criteria. Several chemical parameters (fasting plasma glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and microalbuminuria), and related chronic vascular complications were measured and recorded in data forms. RESULTS: Logistic regressions were used to analyse odds ratios between uric acid/microalbuminuria levels and several chronic vascular complications. Prevalence of chronic vascular complications in T2DM patients, namely coronary arterial disease, cerebrovascular disease, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy was significantly correlated with increase of uric acid level [2.29 (1.01-5.2), 16.01 (4.74-54.09), 9.99 (4.4-22.8), 4.43 (1.3-15.1), 4.37 (1.5-12.9)], and of microalbuminuria level [7.0 (3.6-13.8), 3.2 (1.2-8.7), NA, 14.7 (5.1-42.7), 7.2 (2.9-17.7)]. CONCLUSION: Both elevated uric acid and microalbuminuria levels were significantly associated with diabetic chronic micro/macro-vascular complications. Monitoring of uric acid and microalbuminuria levels provides a predictive value for a presence of chronic micro/macro-vascular complications in patients with type 2 diabetes.
AIMS: To investigate an association between serum uric acid/microalbuminuria and chronic micro/macro-vascular complications in type 2 diabeticpatients. METHODS: This cross-sectional study enrolled 608 patients with type 2 diabetes. All subjects were examined and basic information on health of the subjects was recorded for inclusion criteria. Several chemical parameters (fasting plasma glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and microalbuminuria), and related chronic vascular complications were measured and recorded in data forms. RESULTS: Logistic regressions were used to analyse odds ratios between uric acid/microalbuminuria levels and several chronic vascular complications. Prevalence of chronic vascular complications in T2DM patients, namely coronary arterial disease, cerebrovascular disease, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy was significantly correlated with increase of uric acid level [2.29 (1.01-5.2), 16.01 (4.74-54.09), 9.99 (4.4-22.8), 4.43 (1.3-15.1), 4.37 (1.5-12.9)], and of microalbuminuria level [7.0 (3.6-13.8), 3.2 (1.2-8.7), NA, 14.7 (5.1-42.7), 7.2 (2.9-17.7)]. CONCLUSION: Both elevated uric acid and microalbuminuria levels were significantly associated with diabetic chronic micro/macro-vascular complications. Monitoring of uric acid and microalbuminuria levels provides a predictive value for a presence of chronic micro/macro-vascular complications in patients with type 2 diabetes.
Authors: Emin Murat Akbas; Aysu Timuroglu; Adalet Ozcicek; Fatih Ozcicek; Levent Demirtas; Adem Gungor; Nergis Akbas Journal: Int J Clin Exp Med Date: 2014-12-15
Authors: Maria Teresa Verrone Quilici; Fernando de Sá Del Fiol; Alexandre Eduardo Franzin Vieira; Maria Inês Toledo Journal: J Diabetes Res Date: 2016-02-22 Impact factor: 4.011