Emin Murat Akbas1, Aysu Timuroglu2, Adalet Ozcicek2, Fatih Ozcicek2, Levent Demirtas2, Adem Gungor3, Nergis Akbas4. 1. Department of Endocrinology, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey. 2. Department of Internal Medicine, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey. 3. Department of Endocrinology, School of Medicine, Ataturk University Erzurum, Turkey. 4. Department of Biochemistry, School of Medicine, Ataturk University Erzurum, Turkey.
Abstract
BACKGROUND: The associations of serum uric acid (UA), atherogenic index of plasma (AIP) and albuminuria with cardiovascular disease have been shown. Several studies focused on association of serum UA and dyslipidemia, serum UA and renal impairment, dyslipidemia and renal impairment. However, to date, in literature, there have been no studies demonstrating the relationship between these parameters in diabetic patients together. AIMS: We aimed to investigate the association between serum UA, albuminuria and AIP in diabetic patients. METHODS: This was a retrospective study involving data of 645 diabetic patients. The patients were separated into groups according to their serum uric acid and AIP levels. The quantitative urine albumin/creatinine ratio in morning spot urine samples were used for standard albuminuria determination. Serum uric acid levels under 6 mg/dL were considered as normal. AIP was calculated as the logarithmically transformed ratio of triglyceride to high density lipoprotein cholesterol. RESULTS: AIP and albuminuria levels were high in high serum UA group compared to normal UA group. Uric acid and albuminuria tended to increase with increasing AIP. Correlation analysis showed that albuminuria, AIP and UA were significantly correlated with each other. Additionally, in binary logistic regression analysis, AIP was found to be independently associated with high UA levels. CONCLUSIONS: Present study reveals that serum UA, AIP and albuminuria are closely related. Physicians should be aware that patients with concomitant hyperuricemia, albuminuria and high AIP are at increased risk of developing cardiovascular disease. Our study confirms that there is a need for larger prospective studies to determine the mechanisms underlying the association of serum UA, AIP and albuminuria.
BACKGROUND: The associations of serum uric acid (UA), atherogenic index of plasma (AIP) and albuminuria with cardiovascular disease have been shown. Several studies focused on association of serum UA and dyslipidemia, serum UA and renal impairment, dyslipidemia and renal impairment. However, to date, in literature, there have been no studies demonstrating the relationship between these parameters in diabeticpatients together. AIMS: We aimed to investigate the association between serum UA, albuminuria and AIP in diabeticpatients. METHODS: This was a retrospective study involving data of 645 diabeticpatients. The patients were separated into groups according to their serum uric acid and AIP levels. The quantitative urine albumin/creatinine ratio in morning spot urine samples were used for standard albuminuria determination. Serum uric acid levels under 6 mg/dL were considered as normal. AIP was calculated as the logarithmically transformed ratio of triglyceride to high density lipoprotein cholesterol. RESULTS: AIP and albuminuria levels were high in high serum UA group compared to normal UA group. Uric acid and albuminuria tended to increase with increasing AIP. Correlation analysis showed that albuminuria, AIP and UA were significantly correlated with each other. Additionally, in binary logistic regression analysis, AIP was found to be independently associated with high UA levels. CONCLUSIONS: Present study reveals that serum UA, AIP and albuminuria are closely related. Physicians should be aware that patients with concomitant hyperuricemia, albuminuria and high AIP are at increased risk of developing cardiovascular disease. Our study confirms that there is a need for larger prospective studies to determine the mechanisms underlying the association of serum UA, AIP and albuminuria.
Entities:
Keywords:
Uric acid; albuminuria; atherogenic index of plasma
Authors: Seo Young Kim; James P Guevara; Kyoung Mi Kim; Hyon K Choi; Daniel F Heitjan; Daniel A Albert Journal: Arthritis Care Res (Hoboken) Date: 2010-02 Impact factor: 4.794
Authors: Leo K Niskanen; David E Laaksonen; Kristiina Nyyssönen; Georg Alfthan; Hanna-Maaria Lakka; Timo A Lakka; Jukka T Salonen Journal: Arch Intern Med Date: 2004-07-26
Authors: Helen M Colhoun; D John Betteridge; Paul N Durrington; Graham A Hitman; H Andrew W Neil; Shona J Livingstone; Valentine Charlton-Menys; David A DeMicco; John H Fuller Journal: Am J Kidney Dis Date: 2009-06-21 Impact factor: 8.860
Authors: Ashuin Kammar-García; Patricia López-Moreno; María Elena Hernández-Hernández; Angélica María Ortíz-Bueno; María de Lurdez Consuelo Martínez-Montaño Journal: Proc (Bayl Univ Med Cent) Date: 2020-08-21