Literature DB >> 2441243

Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements.

S G Widen, J Papaconstantinou.   

Abstract

alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene.

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Year:  1987        PMID： 2441243      PMCID： PMC365398          DOI： 10.1128/mcb.7.7.2606-2609.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  30 in total

1.  Cell type-specific enhancer element associated with a mouse MHC gene, E beta.

Authors:  S D Gillies; V Folsom; S Tonegawa
Journal:  Nature       Date:  1984 Aug 16-22       Impact factor: 49.962

2.  Molecular mechanism of extinction of liver-specific functions in mouse hepatoma x rat fibroblast hybrids: extinction of the albumin gene.

Authors:  J Papaconstantinou; E Wong; H Ratrie; C Szpirer; J Szpirer
Journal:  Somatic Cell Genet       Date:  1982-05

3.  Potency of extinction of albumin and alpha-foetoprotein production in mouse hepatoma-fibroblasts hybrids.

Authors:  A Poliard
Journal:  Cell Biol Int Rep       Date:  1981-11

4.  A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

Authors:  S D Gillies; S L Morrison; V T Oi; S Tonegawa
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

5.  Immunoglobulin gene transcription is activated by downstream sequence elements.

Authors:  C Queen; D Baltimore
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

6.  A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

Authors:  J Banerji; L Olson; W Schaffner
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

7.  Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes.

Authors:  M D Walker; T Edlund; A M Boulet; W J Rutter
Journal:  Nature       Date:  1983 Dec 8-14       Impact factor: 49.962

8.  A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells.

Authors:  A M Killary; R E Fournier
Journal:  Cell       Date:  1984-09       Impact factor: 41.582

9.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

10.  Molecular mechanisms of extinction of liver-specific functions in mouse hepatoma rat fibroblast hybrids: extinction of alpha-fetoprotein gene.

Authors:  W K Church; J Papaconstantinou; S W Kwan; A Poliard; C Szpirer; J Szpirer
Journal:  Somat Cell Mol Genet       Date:  1984-09
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  4 in total

1.  Combinatorial control of positive and negative, upstream and intragenic regulatory DNA domains of the mouse alpha 1-foetoprotein gene.

Authors:  M Molné; C Houart; J Szpirer; C Szpirer
Journal:  Nucleic Acids Res       Date:  1989-05-11       Impact factor: 16.971

2.  The alpha-foetoprotein proximal enhancer: localization, cell specificity and modulation by dexamethasone.

Authors:  C Houart; J Szpirer; C Szpirer
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

3.  Derepression of a mouse alpha-fetoprotein expression vector in COS-1 cells by amplification of specific cis-acting sequences of the AFP promoter.

Authors:  J P Rabek; P R Hoyt; D E Zhang; M G Izban; J Papaconstantinou
Journal:  Nucleic Acids Res       Date:  1990-11-25       Impact factor: 16.971

4.  Multiple regulatory elements of the murine gamma 2-crystallin promoter.

Authors:  S Lok; W Stevens; M L Breitman; L C Tsui
Journal:  Nucleic Acids Res       Date:  1989-05-11       Impact factor: 16.971
  4 in total

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