Literature DB >> 24409397

In-the-plane design of an off-axis ophthalmic adaptive optics system using toroidal mirrors.

Zhuolin Liu1, Omer P Kocaoglu2, Donald T Miller3.   

Abstract

Adaptive optics (AO) ophthalmoscopes have garnered increased clinical and scientific use for imaging the microscopic retina. Unlike conventional ophthalmoscopes, however, AO systems are commonly designed with spherical mirrors that must be used off-axis. This arrangement causes astigmatism to accumulate at the retina and pupil conjugate planes, degrading AO performance. To mitigate this effect and more fully tap the benefit of AO, we investigated a novel solution based on toroidal mirrors. Derived 2(nd) order analytic solutions along with commercial ray tracing predict performance benefit of toroidal mirrors for ophthalmoscopic use. For the Indiana AO ophthalmoscope, a minimum of three toroids is required to achieve performance criteria for retinal image quality, beam displacement, and beam ellipticity. Measurements with fabricated toroids and retinal imaging on subjects substantiate the theoretical predictions. Comparison to off-the-plane method is also presented.

Entities:  

Keywords:  (010.1080) Active or adaptive optics; (080.4035) Mirror system design; (110.4500) Optical coherence tomography; (170.4460) Ophthalmic optics and devices; (330.5310) Vision - photoreceptors

Year:  2013        PMID: 24409397      PMCID: PMC3862155          DOI: 10.1364/BOE.4.003007

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN: 2156-7085            Impact factor:   3.732


  23 in total

1.  Confocal scanning laser ophthalmoscope.

Authors:  R H Webb; G W Hughes; F C Delori
Journal:  Appl Opt       Date:  1987-04-15       Impact factor: 1.980

2.  MEMS-based adaptive optics scanning laser ophthalmoscopy.

Authors:  Yuhua Zhang; Siddharth Poonja; Austin Roorda
Journal:  Opt Lett       Date:  2006-05-01       Impact factor: 3.776

3.  Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope.

Authors:  Stephen A Burns; Remy Tumbar; Ann E Elsner; Daniel Ferguson; Daniel X Hammer
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2007-05       Impact factor: 2.129

4.  Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions.

Authors:  Robert J Zawadzki; Stacey S Choi; Steven M Jones; Scot S Oliver; John S Werner
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  2007-05       Impact factor: 2.129

5.  High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography.

Authors:  Yan Zhang; Barry Cense; Jungtae Rha; Ravi S Jonnal; Weihua Gao; Robert J Zawadzki; John S Werner; Steve Jones; Scot Olivier; Donald T Miller
Journal:  Opt Express       Date:  2006-05-15       Impact factor: 3.894

6.  Supernormal vision and high-resolution retinal imaging through adaptive optics.

Authors:  J Liang; D R Williams; D T Miller
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  1997-11       Impact factor: 2.129

7.  First-order design of off-axis reflective ophthalmic adaptive optics systems using afocal telescopes.

Authors:  Armando Gómez-Vieyra; Alfredo Dubra; Daniel Malacara-Hernández; David R Williams
Journal:  Opt Express       Date:  2009-10-12       Impact factor: 3.894

8.  Reflective afocal broadband adaptive optics scanning ophthalmoscope.

Authors:  Alfredo Dubra; Yusufu Sulai
Journal:  Biomed Opt Express       Date:  2011-05-27       Impact factor: 3.732

9.  Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope.

Authors:  Alfredo Dubra; Yusufu Sulai; Jennifer L Norris; Robert F Cooper; Adam M Dubis; David R Williams; Joseph Carroll
Journal:  Biomed Opt Express       Date:  2011-06-08       Impact factor: 3.732

10.  Phase-sensitive imaging of the outer retina using optical coherence tomography and adaptive optics.

Authors:  Ravi S Jonnal; Omer P Kocaoglu; Qiang Wang; Sangyeol Lee; Donald T Miller
Journal:  Biomed Opt Express       Date:  2011-12-13       Impact factor: 3.732

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  28 in total

1.  Modal content of living human cone photoreceptors.

Authors:  Zhuolin Liu; Omer P Kocaoglu; Timothy L Turner; Donald T Miller
Journal:  Biomed Opt Express       Date:  2015-08-17       Impact factor: 3.732

2.  High-speed adaptive optics for imaging of the living human eye.

Authors:  Yongxin Yu; Tianjiao Zhang; Alexander Meadway; Xiaolin Wang; Yuhua Zhang
Journal:  Opt Express       Date:  2015-09-07       Impact factor: 3.894

3.  Author Response: Outer Retinal Bands.

Authors:  Ravi S Jonnal; Omer P Kocaoglu; Robert J Zawadzki; Sang-Hyuck Lee; John S Werner; Donald T Miller
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-04       Impact factor: 4.799

4.  Adaptive optics optical coherence tomography at 1 MHz.

Authors:  Omer P Kocaoglu; Timothy L Turner; Zhuolin Liu; Donald T Miller
Journal:  Biomed Opt Express       Date:  2014-11-06       Impact factor: 3.732

5.  In vivo measurement of organelle motility in human retinal pigment epithelial cells.

Authors:  Zhuolin Liu; Kazuhiro Kurokawa; Daniel X Hammer; Donald T Miller
Journal:  Biomed Opt Express       Date:  2019-07-19       Impact factor: 3.732

6.  Design of two spherical mirror unobscured relay telescopes using nodal aberration theory.

Authors:  Samuel Steven; Julie Bentley; Alfredo Dubra
Journal:  Opt Express       Date:  2019-04-15       Impact factor: 3.894

7.  Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.

Authors:  James Polans; Brenton Keller; Oscar M Carrasco-Zevallos; Francesco LaRocca; Elijah Cole; Heather E Whitson; Eleonora M Lad; Sina Farsiu; Joseph A Izatt
Journal:  Biomed Opt Express       Date:  2016-12-02       Impact factor: 3.732

8.  Influence of wave-front sampling in adaptive optics retinal imaging.

Authors:  Marie Laslandes; Matthias Salas; Christoph K Hitzenberger; Michael Pircher
Journal:  Biomed Opt Express       Date:  2017-01-24       Impact factor: 3.732

9.  Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris [Invited].

Authors:  Kazuhiro Kurokawa; Zhuolin Liu; Donald T Miller
Journal:  Biomed Opt Express       Date:  2017-02-24       Impact factor: 3.732

10.  Photoreceptor disc shedding in the living human eye.

Authors:  Omer P Kocaoglu; Zhuolin Liu; Furu Zhang; Kazuhiro Kurokawa; Ravi S Jonnal; Donald T Miller
Journal:  Biomed Opt Express       Date:  2016-10-13       Impact factor: 3.732

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