Parthasaradhi Reddy Tanguturi1, Bhoomireddy Pullareddy2, B S Rama Krishna3, Dwarkanath K Murthy4. 1. Department of Genetics, Osmania University, Hyderabad 500013, A.P., India. 2. Department of Cell and Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad 500013, A.P., India. 3. Department of Animal Sciences, University of Hyderabad, Hyderabad 50013, A.P., India. 4. Department of Genetics, Osmania University, Hyderabad 500013, A.P., India. Electronic address: dwarkanath49@yahoo.co.in.
Abstract
INTRODUCTION: Studies have reported an association between lipoprotein lipase (LPL) gene and myocardial infarction in some populations. Therefore, the present study aimed to investigate the association of the HindIII polymorphism of the (LPL) gene with myocardial infarction and to explore its potential role in susceptibility in a South Indian population. SUBJECTS AND METHODS: We included a total of 412 subjects (202 myocardial infarction patients and 210 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the LPL gene HindIII polymorphism was determined by polymerase chain reaction. RESULTS: Comparison of the lipid profiles between patients and controls showed that patients had statistically high significant values (p = 0.0001). The H(+) H(+) genotype of the LPL gene is associated with myocardial infarction. H(+) H(+) vs. H(-) H(-) was χ2 = 19.4, OR 3.1, CI 95% 1.8-5.2, p < 0.0001. CONCLUSION: Our study strongly suggests that the LPL gene HindIII Hþ Hþ genotype is an independent risk factor for first MI.
INTRODUCTION: Studies have reported an association between lipoprotein lipase (LPL) gene and myocardial infarction in some populations. Therefore, the present study aimed to investigate the association of the HindIII polymorphism of the (LPL) gene with myocardial infarction and to explore its potential role in susceptibility in a South Indian population. SUBJECTS AND METHODS: We included a total of 412 subjects (202 myocardial infarctionpatients and 210 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the LPL gene HindIII polymorphism was determined by polymerase chain reaction. RESULTS: Comparison of the lipid profiles between patients and controls showed that patients had statistically high significant values (p = 0.0001). The H(+) H(+) genotype of the LPL gene is associated with myocardial infarction. H(+) H(+) vs. H(-) H(-) was χ2 = 19.4, OR 3.1, CI 95% 1.8-5.2, p < 0.0001. CONCLUSION: Our study strongly suggests that the LPL gene HindIII Hþ Hþ genotype is an independent risk factor for first MI.
Authors: Yan Qin Ma; G Neil Thomas; Maggie C Y Ng; Julian A J H Critchley; Juliana C N Chan; Brian Tomlinson Journal: Metabolism Date: 2003-03 Impact factor: 8.694
Authors: Renato Scacchi; Giuseppe Gambina; Elisabetta Broggio; Giuseppe Moretto; Maria Ruggeri; Rosa Maria Corbo Journal: Neurosci Lett Date: 2004-09-02 Impact factor: 3.046
Authors: Israa M Shatwan; Anne-Marie Minihane; Christine M Williams; Julie A Lovegrove; Kim G Jackson; Karani S Vimaleswaran Journal: Int J Mol Sci Date: 2016-03-18 Impact factor: 5.923
Authors: N G Kukava; B V Titov; G J Osmak; N A Matveeva; O G Kulakova; A V Favorov; R M Shakhnovich; M Ya Ruda; O O Favorova Journal: Acta Naturae Date: 2017 Oct-Dec Impact factor: 1.845