Prabitha Urwyler1, Tobias Nef2, Alison Killen3, Daniel Collerton4, Alan Thomas4, David Burn3, Ian McKeith3, Urs Peter Mosimann5. 1. Gerontechnology & Rehabilitation Group, University of Bern, Bern, Switzerland. 2. Gerontechnology & Rehabilitation Group, University of Bern, Bern, Switzerland; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. 3. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom. 4. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Northumberland, Tyne & Wear NHS Foundation Trust, Bensham Hospital, Gateshead, United Kingdom. 5. Gerontechnology & Rehabilitation Group, University of Bern, Bern, Switzerland; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Old Age Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland. Electronic address: urs.mosimann@gef.be.ch.
Abstract
BACKGROUND: Visual symptoms are common in Parkinson's disease (PD) and are frequently under-diagnosed. The detection of visual symptoms is important for differential diagnosis and patient management. AIM: To establish the prevalence of recurrent visual complaints (RVC) and recurrent visual hallucinations (RVH) and to investigate their interaction in PD patients and controls. METHODS: This cross-sectional study included 88 PD patients and 90 controls. RVC and RVH were assessed with a visual symptom questionnaire and the North-East-Visual-Hallucinations-Interview (NEVHI). RESULTS: Double vision (PD vs. CONTROLS: 18.2% vs. 1.3%; p < 0.001), misjudging objects when walking (PD vs. CONTROLS: 12.5% vs. 1.3%; p < 0.01), words moving whilst reading (PD vs. CONTROLS: 17.0% vs. 1.3%; p < 0.001) and freezing in narrow spaces (PD vs. CONTROLS: 30.7% vs. 0%; p < 0.001) were almost exclusively found in PD patients. The same was true for recurrent complex visual hallucinations and illusions (PD vs. CONTROLS: both 17.0% vs. 0%; p < 0.001). Multiple RVC (43.2% vs. 15.8%) and multiple RVH (29.5% vs. 5.6%) were also more common in PD patients (both p < 0.001). RVC did not predict recurrent complex visual hallucinations; but double vision (p = 0.018, R(2) = 0.302) and misjudging objects (p = 0.002, R(2) = 0.302) predicted passage hallucinations. Misjudging objects also predicted the feeling of presence (p = 0.010, R(2) = 0.321). CONCLUSIONS: Multiple and recurrent visual symptoms are common in PD. RVC emerged as risk factors predictive of the minor forms of hallucinations, but not recurrent complex visual hallucinations.
BACKGROUND:Visual symptoms are common in Parkinson's disease (PD) and are frequently under-diagnosed. The detection of visual symptoms is important for differential diagnosis and patient management. AIM: To establish the prevalence of recurrent visual complaints (RVC) and recurrent visual hallucinations (RVH) and to investigate their interaction in PDpatients and controls. METHODS: This cross-sectional study included 88 PDpatients and 90 controls. RVC and RVH were assessed with a visual symptom questionnaire and the North-East-Visual-Hallucinations-Interview (NEVHI). RESULTS: Double vision (PD vs. CONTROLS: 18.2% vs. 1.3%; p < 0.001), misjudging objects when walking (PD vs. CONTROLS: 12.5% vs. 1.3%; p < 0.01), words moving whilst reading (PD vs. CONTROLS: 17.0% vs. 1.3%; p < 0.001) and freezing in narrow spaces (PD vs. CONTROLS: 30.7% vs. 0%; p < 0.001) were almost exclusively found in PDpatients. The same was true for recurrent complex visual hallucinations and illusions (PD vs. CONTROLS: both 17.0% vs. 0%; p < 0.001). Multiple RVC (43.2% vs. 15.8%) and multiple RVH (29.5% vs. 5.6%) were also more common in PDpatients (both p < 0.001). RVC did not predict recurrent complex visual hallucinations; but double vision (p = 0.018, R(2) = 0.302) and misjudging objects (p = 0.002, R(2) = 0.302) predicted passage hallucinations. Misjudging objects also predicted the feeling of presence (p = 0.010, R(2) = 0.321). CONCLUSIONS: Multiple and recurrent visual symptoms are common in PD. RVC emerged as risk factors predictive of the minor forms of hallucinations, but not recurrent complex visual hallucinations.
Authors: Christoph Mueller; Anto P Rajkumar; Yi Min Wan; Latha Velayudhan; Dominic Ffytche; Kallol Ray Chaudhuri; Dag Aarsland Journal: CNS Drugs Date: 2018-07 Impact factor: 5.749
Authors: Femke Visser; Annemarie M M Vlaar; Carlijn D J M Borm; Valentin Apostolov; Y X Lee; Irene C Notting; Henry C Weinstein; Henk W Berendse Journal: J Neurol Date: 2019-06-18 Impact factor: 4.849
Authors: Rimona S Weil; Anette E Schrag; Jason D Warren; Sebastian J Crutch; Andrew J Lees; Huw R Morris Journal: Brain Date: 2016-11-01 Impact factor: 15.255