| Literature DB >> 24405673 |
Jerome S Menet1, Paul E Hardin2.
Abstract
The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.Entities:
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Year: 2014 PMID: 24405673 PMCID: PMC4157344 DOI: 10.1016/j.cub.2013.11.016
Source DB: PubMed Journal: Curr Biol ISSN: 0960-9822 Impact factor: 10.834