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Literature DB >> 24400322

Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate.

Francesca P A Fabbiani¹, Gernot Buth, Demetrius C Levendis, Aurora J Cruz-Cabeza.

Abstract

The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.

Entities: Chemical

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Year: 2014 PMID： 24400322 DOI： 10.1039/c3cc48466a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

7 in total

1. New method to compute Rcomplete enables maximum likelihood refinement for small datasets.

Authors: Jens Luebben; Tim Gruene
Journal: Proc Natl Acad Sci U S A Date: 2015-07-06 Impact factor: 11.205

2. Computational and Experimental Characterization of Five Crystal Forms of Thymine: Packing Polymorphism, Polytypism/Disorder and Stoichiometric 0.8-Hydrate.

Authors: Doris E Braun; Thomas Gelbrich; Klaus Wurst; Ulrich J Griesser
Journal: Cryst Growth Des Date: 2016-06-01 Impact factor: 4.076

3. Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening.

Authors: M A Neumann; J van de Streek; F P A Fabbiani; P Hidber; O Grassmann
Journal: Nat Commun Date: 2015-07-22 Impact factor: 14.919

Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate.

1. New method to compute Rcomplete enables maximum likelihood refinement for small datasets.

2. Computational and Experimental Characterization of Five Crystal Forms of Thymine: Packing Polymorphism, Polytypism/Disorder and Stoichiometric 0.8-Hydrate.

3. Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening.

Review 4. High-pressure crystallography of periodic and aperiodic crystals.

5. Pressure-Induced Polymorphism of Caprolactam: A Neutron Diffraction Study.

6. Experimental and Computational Hydrate Screening: Cytosine, 5-Flucytosine and Their Solid Solution.

Review 7. Supramolecular interactions in the solid state.