| Literature DB >> 24399259 |
Li He1, Wen-Juan Wu1, Jian-Kang Yang2, Hui Cheng3, Xian-Bo Zuo3, Wei Lai4, Tian-Wen Gao5, Cui-Lin Ma5, Na Luo6, Jian-Qing Huang7, Feng-Yan Lu8, Ye-Qiang Liu9, Yi-Jin Huang10, Qian-Jin Lu11, Huai-Liang Zhang12, Lin Wang13, Wei-Zhen Wang14, Mei-Mei Wang15, Sheng-Xiang Xiao16, Qing Sun17, Chun-Yang Li17, Yan-Ping Bai18, Hui Li19, Zhan-Chao Zhou20, Fu-Sheng Zhou3, Gang Chen3, Bo Liang3, Jue Qi21, Xiao-Yan Yang21, Ting Yang21, Xing Zheng22, Liang-Dan Sun3, Xue-Jun Zhang3, Ya-Ping Zhang22.
Abstract
Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, P(combined)=4.41 × 10⁻⁹ and rs1060573, P(combined)=1.28 × 10⁻⁸) and 1q24.2 (SELL, rs7531806, P(combined)=1.20 × 10⁻⁸) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne.Entities:
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Year: 2014 PMID： 24399259 DOI： 10.1038/ncomms3870
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919