| Literature DB >> 25007882 |
Mei-Hua Guo1, Wen-Juan Wu1, Long Fan2, Min-Sheng Peng3, Jian-Kang Yang4, Wen Zhang5, Fei Hao6, Hong-Fu Xie7, Lei-Hong Xiang8, Min Zheng9, Yan-Ni Guo10, Qing-Hua Song11, Cai-Xia Tu12, Hua Zhong13, Wen-Ge Fan14, Yue-Jun Shi15, Ping Cao16, Lian-Yuan Feng17, Meng Na18, Qin Pang19, Xiao-Yan Yang19, Cheng Yang19, Xi Zou19, Li He1, Ya-Ping Zhang20.
Abstract
Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.Entities:
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Year: 2014 PMID： 25007882 DOI： 10.1038/jhg.2014.53
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172