| Literature DB >> 24398385 |
Madiha Sahar Khan1, Munawar Ali Munawar2, Mohammad Ashraf3, Umber Alam3, Athar Ata4, Abdullah Mohamed Asiri5, Samina Kousar1, Misbahul Ain Khan6.
Abstract
A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their α-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis techniques.Entities:
Keywords: 1,2-Di(11H-indeno[2,1-b]quioxalin-11-ylidene)hydrazine; 11H-Indeno[1,2-b]quinoxalin-11-one; N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazides; α-Glucosidase inhibitors
Mesh：
Substances：
Year: 2013 PMID： 24398385 DOI： 10.1016/j.bmc.2013.12.024
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641