Literature DB >> 2439634

Decay-accelerating factor. Genetic polymorphism and linkage to the RCA (regulator of complement activation) gene cluster in humans.

J Rey-Campos, P Rubinstein, S Rodriguez de Cordoba.   

Abstract

We have investigated the genetic relationships between the human decay-accelerating factor (DAF) and a group of complement components including the C3b/C4b receptor (CR1), C4-binding protein (C4bp), and factor H (H), to which DAF is structurally and functionally related. CR1, C4bp, and H were previously demonstrated to be encoded by a cluster of closely linked genes, which we have designated regulator of complement activation (RCA). Southern blot analysis of genomic DNA using a DAF cDNA probe unraveled the existence of restriction fragment length polymorphism (RFLP) for both Bam HI and Hind III restriction endonucleases. Segregation analysis of these polymorphic fragments in families informative for the segregation of alleles at the CR1, C4BP, and H loci (RCA-haplotypes), demonstrated that, in humans, the gene encoding DAF is located within the RCA gene cluster. No recombinants between DAF and C4BP/CR1 were encountered in 32 informative meioses. In addition, in two individuals showing recombination between the CR1/C4BP and H loci, DAF segregated with the CR1/C4BP segment. Thus, the DAF gene maps closer to the CR1/C4BP loci than to the H gene, from which it can be separated by genetic recombination.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2439634      PMCID： PMC2188646          DOI： 10.1084/jem.166.1.246

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  New alleles of C4-binding protein and factor H and further linkage data in the regulator of complement activation (RCA) gene cluster in man.

Authors:  S Rodriguez de Cordoba; P Rubinstein
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

2.  Assignment of the structural gene for the third component of human complement to chromosome 19.

Authors:  A S Whitehead; E Solomon; S Chambers; W F Bodmer; S Povey; G Fey
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

3.  High resolution isoelectric focusing of immunoprecipitated proteins under denaturing conditions. A simple analytical method applied to the study of complement component polymorphisms.

Authors:  S Rodriguez de Córdoba; P Rubinstein; A Ferreira
Journal:  J Immunol Methods       Date:  1984-04-27       Impact factor: 2.303

Review 4.  The complement components of the major histocompatibility locus.

Authors:  R R Porter
Journal:  CRC Crit Rev Biochem       Date:  1984

5.  Evidence for linkage between the loci coding for the binding protein for the fourth component of human complement (C4BP) and for the C3b/C4b receptor.

Authors:  S Rodriguez de Cordoba; T R Dykman; F Ginsberg-Fellner; G Ercilla; M Aqua; J P Atkinson; P Rubinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

6.  Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines.

Authors:  J L Cole; G A Housley; T R Dykman; R P MacDermott; J P Atkinson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

7.  Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria.

Authors:  M K Pangburn; R D Schreiber; H J Müller-Eberhard
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Murine complement component 3: genetic variation and linkage to H-2.

Authors:  F P Da Silva; G F Hoecker; N K Day; K Vienne; P Rubinstein
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

9.  Paroxysmal nocturnal hemoglobinuria: deficiency in factor H-like functions of the abnormal erythrocytes.

Authors:  M K Pangburn; R D Schreiber; J S Trombold; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1983-06-01       Impact factor: 14.307

10.  Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes.

Authors:  M E Medof; T Kinoshita; V Nussenzweig
Journal:  J Exp Med       Date:  1984-11-01       Impact factor: 14.307
View more
  17 in total

1.  Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants.

Authors:  D M Lublin; E S Thompson; A M Green; C Levene; M J Telen
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

Review 2.  The future use of complement inhibitors for the treatment of neurological diseases.

Authors:  E G McGeer; P L McGeer
Journal:  Drugs       Date:  1998-06       Impact factor: 9.546

3.  Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.

Authors:  H A Stafford; M L Tykocinski; D M Lublin; V M Holers; W F Rosse; J P Atkinson; M E Medof
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

4.  Coagulation factor XIII B subunit is encoded by a gene linked to the regulator of complement activation (RCA) gene cluster in man.

Authors:  S Rodriguez de Cordoba; J Rey-Campos; D D Dykes; P J McAlpine; P Wong; P Rubinstein
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

5.  C4BPAL2: a second duplication of the C4BPA gene in the human RCA gene cluster.

Authors:  F Pardo-Manuel de Villena; S Rodríguez de Córdoba
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

Review 6.  Membrane proteins that protect against complement lysis.

Authors:  B P Morgan; S Meri
Journal:  Springer Semin Immunopathol       Date:  1994

7.  Studies on the defect which causes absence of decay accelerating factor (DAF) from the peripheral blood cells of an individual with the Inab phenotype.

Authors:  C G Tate; M Uchikawa; M J Tanner; P A Judson; S F Parsons; G Mallinson; D J Anstee
Journal:  Biochem J       Date:  1989-07-15       Impact factor: 3.857

Review 8.  New insights into postrenal transplant hemolytic uremic syndrome.

Authors:  Julien Zuber; Moglie Le Quintrec; Rebecca Sberro-Soussan; Chantal Loirat; Véronique Frémeaux-Bacchi; Christophe Legendre
Journal:  Nat Rev Nephrol       Date:  2010-11-23       Impact factor: 28.314

9.  Human genes for the alpha and beta chains of complement C4b-binding protein are closely linked in a head-to-tail arrangement.

Authors:  F Pardo-Manuel; J Rey-Campos; A Hillarp; B Dahlbäck; S Rodriguez de Cordoba
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

10.  A partial cDNA clone of trypomastigote decay-accelerating factor (T-DAF), a developmentally regulated complement inhibitor of Trypanosoma cruzi, has genetic and functional similarities to the human complement inhibitor DAF.

Authors:  D V Tambourgi; T L Kipnis; W D da Silva; K A Joiner; A Sher; S Heath; B F Hall; G B Ogden
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.