PURPOSE: Studies have previously examined the relation between a single measure of plasma fatty acids and risk of heart failure. However, it is unclear whether the use of repeated measures of fatty acids over time is required for the assessment of omega-3 fatty acids heart failure relation. METHODS: Using a nested case-control design, this ancillary study used 421 cases and 421 matched controls from the Physicians' Health Study to assess the variability of plasma phospholipid fatty acids over time and compare the results of omega-3 fatty acids heart failure associations using a single versus repeated measurements of plasma phospholipid fatty acids. Plasma omega-3 fatty acids were measured at baseline (1982) and approximately 15 years later using gas chromatography. RESULTS: Spearman's correlation coefficients between baseline and follow-up measures of α-linolenic acid (ALA), EPA, DPA, and DHA were 0.20, 0.45, 0.28, and 0.50, respectively, in the control series. Multivariable adjusted odds ratios for heart failure per standard deviation higher plasma ALA were 0.98 (95% CI 0.85-1.13) when using baseline ALA and 0.86 (95% CI 0.74-1.01) when using the average of baseline and follow-up ALA measurements. Corresponding odds ratios for total long chain omega-3 FAs (EPA + DHA + DPA) were 0.87 (0.73-1.03) and 0.88 (0.75-1.04). CONCLUSIONS: Our data demonstrate modest correlation between measurements of plasma phospholipid fatty acids spaced by 15 years. A single measurement of plasma phospholipid fatty acids appears reasonable to estimate the risk of heart failure over long-term follow-up.
PURPOSE: Studies have previously examined the relation between a single measure of plasma fatty acids and risk of heart failure. However, it is unclear whether the use of repeated measures of fatty acids over time is required for the assessment of omega-3 fatty acidsheart failure relation. METHODS: Using a nested case-control design, this ancillary study used 421 cases and 421 matched controls from the Physicians' Health Study to assess the variability of plasma phospholipid fatty acids over time and compare the results of omega-3 fatty acidsheart failure associations using a single versus repeated measurements of plasma phospholipid fatty acids. Plasma omega-3 fatty acids were measured at baseline (1982) and approximately 15 years later using gas chromatography. RESULTS: Spearman's correlation coefficients between baseline and follow-up measures of α-linolenic acid (ALA), EPA, DPA, and DHA were 0.20, 0.45, 0.28, and 0.50, respectively, in the control series. Multivariable adjusted odds ratios for heart failure per standard deviation higher plasma ALA were 0.98 (95% CI 0.85-1.13) when using baseline ALA and 0.86 (95% CI 0.74-1.01) when using the average of baseline and follow-up ALA measurements. Corresponding odds ratios for total long chain omega-3 FAs (EPA + DHA + DPA) were 0.87 (0.73-1.03) and 0.88 (0.75-1.04). CONCLUSIONS: Our data demonstrate modest correlation between measurements of plasma phospholipid fatty acids spaced by 15 years. A single measurement of plasma phospholipid fatty acids appears reasonable to estimate the risk of heart failure over long-term follow-up.
Authors: Dariush Mozaffarian; Rozenn N Lemaitre; Irena B King; Xiaoling Song; Donna Spiegelman; Frank M Sacks; Eric B Rimm; David S Siscovick Journal: Ann Intern Med Date: 2011-08-02 Impact factor: 25.391
Authors: Lu Wang; Michael Tsai; Joann E Manson; Luc Djousse; J Michael Gaziano; Julie E Buring; Howard D Sesso Journal: J Nutr Date: 2011-07-06 Impact factor: 4.798
Authors: Rozenn N Lemaitre; Colleen Sitlani; Xiaoling Song; Irena B King; Barbara McKnight; Donna Spiegelman; Frank M Sacks; Luc Djoussé; Eric B Rimm; David S Siscovick; Dariush Mozaffarian Journal: Am J Clin Nutr Date: 2012-06-27 Impact factor: 7.045
Authors: Luc Djoussé; Mary L Biggs; Rozenn N Lemaitre; Irena B King; Xiaoling Song; Joachim H Ix; Kenneth J Mukamal; David S Siscovick; Dariush Mozaffarian Journal: Am J Clin Nutr Date: 2011-05-18 Impact factor: 7.045
Authors: Claudia L Satizabal; Cécilia Samieri; Kendra L Davis-Plourde; Barbara Voetsch; Hugo J Aparicio; Matthew P Pase; José Rafael Romero; Catherine Helmer; Ramachandran S Vasan; Carlos S Kase; Stéphanie Debette; Alexa S Beiser; Sudha Seshadri Journal: Stroke Date: 2018-12 Impact factor: 7.914
Authors: Amy B Karger; Weihua Guan; Sarah O Nomura; Natalie L Weir; Barbara E K Klein; Gregory L Burke; W Craig Johnson; Michael Y Tsai Journal: Retina Date: 2022-07-01 Impact factor: 3.975
Authors: Luc Djoussé; Yuk-Lam Ho; Xuan-Mai T Nguyen; David R Gagnon; Peter W F Wilson; Kelly Cho; J Michael Gaziano Journal: J Am Heart Assoc Date: 2018-04-21 Impact factor: 5.501
Authors: Ju-Sheng Zheng; Fumiaki Imamura; Stephen J Sharp; Albert Koulman; Julian L Griffin; Angela A Mulligan; Robert Luben; Kay-Tee Khaw; Nicholas J Wareham; Nita G Forouhi Journal: Am J Clin Nutr Date: 2019-06-01 Impact factor: 7.045