| Literature DB >> 24393719 |
Taro Toyota1, Hiromichi Fujito2, Akiko Suganami3, Tomoki Ouchi4, Aki Ooishi4, Akira Aoki5, Kazutaka Onoue5, Yutaka Muraki5, Tomoyuki Madono5, Masanori Fujinami6, Yutaka Tamura3, Hideki Hayashi7.
Abstract
Liposomally formulated indocyanine green (LP-ICG) has drawn much attention as a highly sensitive near-infrared (NIR)-fluorescence probe for tumors or lymph nodes in vivo. We synthesized ICG derivatives tagged with alkyl chains (ICG-Cn), and we examined NIR-fluorescence imaging for lymph nodes in the lower extremities of mice by using liposomally formulated ICG-Cn (LP-ICG-Cn) as well as conventional liposomally formulated ICG (LP-ICG) and ICG. Analysis with a noninvasive preclinical NIR-fluorescence imaging system revealed that LP-ICG-Cn accumulates in only the popliteal lymph node 1h after injection into the footpad, whereas LP-ICG and ICG accumulate in the popliteal lymph node and other organs like the liver. This result indicates that LP-ICG-Cn is a useful NIR-fluorescence probe for noninvasive in vivo bioimaging, especially for the sentinel lymph node.Entities:
Keywords: Indocyanine green (ICG); Liposome; Lymph node; Near-infrared (NIR)-fluorescence probe; Phospholipid
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Year: 2013 PMID： 24393719 DOI： 10.1016/j.bmc.2013.12.026
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641