| Literature DB >> 24390674 |
Xiaofei Li1, Wenjun Yang, Lianqing Lou, Yongxin Chen, Shuang Wu, Guoqiang Ding.
Abstract
microRNAs constitute a novel class of small, non-coding RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation. Aberrant miRNA expression has been implicated in the initiation, progression, and metastasis of hepatocellular carcinoma (HCC). It is well-documented that miRNAs function as either tumor suppressor genes or oncogenes in the development and progression of HCC. Additionally, substantial evidence suggests that unique miRNA signatures can serve as valuable diagnostic and prognostic biomarkers for HCC. Interestingly, certain subsets of miRNAs have also been identified as potential therapeutic targets for HCC.Entities:
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Year: 2014 PMID： 24390674 DOI： 10.1007/s10620-013-3006-1
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199