Bamini Gopinath1, Gerald Liew2, George Burlutsky2, Paul Mitchell2. 1. Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW, Australia. Electronic address: bamini.gopinath@sydney.edu.au. 2. Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, NSW, Australia.
Abstract
OBJECTIVES: We aimed to assess the prospective association between age-related macular degeneration (AMD) and impaired activities of daily living (ADL) among a large cohort of older adults. STUDY DESIGN: Functional status was determined by the Older Americans Resources and Services ADL scale from 2002-2004 to 2007-2009 among 761 participants aged 60+ years. AMD was assessed from retinal photographs. RESULTS: After adjusting for age, sex, living status, self-rated poor health, smoking, body mass index, visual impairment, hypertension, diabetes, hospital admissions in the past year, walking disability, probable depression, mini-mental state examination scores, having any AMD or late AMD increased the risk of incident impaired total ADL 5 years later, odds ratio, OR 2.87 (95% confidence intervals, CI 1.44-5.71) and OR 12.95 (95% CI 3.78-44.35), respectively. Having any AMD increased the risk of developing instrumental ADL disability over the 5 years, multivariable-adjusted OR 2.06 (95% CI 1.11-3.83). CONCLUSIONS: This study shows that the presence of AMD could independently signal an increased risk of functional disability, particularly in performing instrumental ADL tasks.
OBJECTIVES: We aimed to assess the prospective association between age-related macular degeneration (AMD) and impaired activities of daily living (ADL) among a large cohort of older adults. STUDY DESIGN: Functional status was determined by the Older Americans Resources and Services ADL scale from 2002-2004 to 2007-2009 among 761 participants aged 60+ years. AMD was assessed from retinal photographs. RESULTS: After adjusting for age, sex, living status, self-rated poor health, smoking, body mass index, visual impairment, hypertension, diabetes, hospital admissions in the past year, walking disability, probable depression, mini-mental state examination scores, having any AMD or late AMD increased the risk of incident impaired total ADL 5 years later, odds ratio, OR 2.87 (95% confidence intervals, CI 1.44-5.71) and OR 12.95 (95% CI 3.78-44.35), respectively. Having any AMD increased the risk of developing instrumental ADL disability over the 5 years, multivariable-adjusted OR 2.06 (95% CI 1.11-3.83). CONCLUSIONS: This study shows that the presence of AMD could independently signal an increased risk of functional disability, particularly in performing instrumental ADL tasks.
Authors: Dimitrios A Karagiannis; Meropi Lygerou; Georgios Papadopoulos; Stamatina A Kabanarou; Miltiadis Aspiotis; Doukas C Dardabounis; Panagiotis G Minakakis; Sofia I Spai; Chrysanthi Koutsandrea; Panagiotis Oikonomidis; Georgia N Pantelopoulou; Olga C Kousidou; Miltiadis Tsilimbaris Journal: Clin Ophthalmol Date: 2020-05-25
Authors: Jo Lane; Emilie M F Rohan; Faran Sabeti; Rohan W Essex; Ted Maddess; Amy Dawel; Rachel A Robbins; Nick Barnes; Xuming He; Elinor McKone Journal: PLoS One Date: 2018-12-31 Impact factor: 3.240