Albert M Li1, Chun T Au2, Crystal Ng2, Hugh S Lam2, Crover K W Ho3, Yun K Wing3. 1. Department of Pediatrics, Department of Psychiatry. Electronic address: albertmli@cuhk.edu.hk. 2. Department of Pediatrics, Department of Psychiatry. 3. Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
Abstract
BACKGROUND: Childhood OSA is a prevalent condition associated with raised BP as documented in cross-sectional studies. This study aimed to determine whether baseline or change in OSA severity was associated with ambulatory BP at 4-year follow-up. METHODS: Children who participated in our previous OSA prevalence research were invited to undergo a repeat overnight sleep study and 24-h ambulatory BP monitoring in this 4-year follow-up study. BP parameters of subjects with differing baseline OSA severity, that is, obstructive apnea-hypopnea index (OAHI) < 1/h, 1 to 5/h, and > 5/h, were compared. Overweight and normal-weight children were analyzed separately. RESULTS: One hundred eighty-five of 306 subjects (60%) were included in the analysis, of whom 58 were overweight at baseline. Linear increasing trends of wake systolic BP (SBP), wake diastolic BP (DBP), and sleep SBP z scores at follow-up were found across groups of increasing baseline OSA severity in the normal weight but not in the overweight subgroup. After adjusting for BMI z score, baseline OAHI was independently associated with all BP z scores at follow-up but not associated with changes in BP z scores across 4 years. On the other hand, change in OAHI was independently associated with sleep SBP and DBP z scores at follow-up and with changes in sleep SBP and DBP z scores across 4 years. CONCLUSIONS: This study provides longitudinal data as additional proof that childhood OSA is associated with elevated BP independent of obesity.
BACKGROUND: Childhood OSA is a prevalent condition associated with raised BP as documented in cross-sectional studies. This study aimed to determine whether baseline or change in OSA severity was associated with ambulatory BP at 4-year follow-up. METHODS:Children who participated in our previous OSA prevalence research were invited to undergo a repeat overnight sleep study and 24-h ambulatory BP monitoring in this 4-year follow-up study. BP parameters of subjects with differing baseline OSA severity, that is, obstructive apnea-hypopnea index (OAHI) < 1/h, 1 to 5/h, and > 5/h, were compared. Overweight and normal-weight children were analyzed separately. RESULTS: One hundred eighty-five of 306 subjects (60%) were included in the analysis, of whom 58 were overweight at baseline. Linear increasing trends of wake systolic BP (SBP), wake diastolic BP (DBP), and sleep SBP z scores at follow-up were found across groups of increasing baseline OSA severity in the normal weight but not in the overweight subgroup. After adjusting for BMI z score, baseline OAHI was independently associated with all BP z scores at follow-up but not associated with changes in BP z scores across 4 years. On the other hand, change in OAHI was independently associated with sleep SBP and DBP z scores at follow-up and with changes in sleep SBP and DBP z scores across 4 years. CONCLUSIONS: This study provides longitudinal data as additional proof that childhood OSA is associated with elevated BP independent of obesity.
Authors: Sherri L Katz; Joanna E MacLean; Lynda Hoey; Linda Horwood; Nicholas Barrowman; Bethany Foster; Stasia Hadjiyannakis; Laurent Legault; Glenda N Bendiak; Valerie G Kirk; Evelyn Constantin Journal: J Clin Sleep Med Date: 2017-09-15 Impact factor: 4.062
Authors: Béatrice Bouhanick; Philippe Sosner; Karine Brochard; Claire Mounier-Véhier; Geneviève Plu-Bureau; Sébastien Hascoet; Bruno Ranchin; Christine Pietrement; Laetitia Martinerie; Jean Marc Boivin; Jean Pierre Fauvel; Justine Bacchetta Journal: Front Pediatr Date: 2021-07-07 Impact factor: 3.418