Literature DB >> 24383813

Lomaiviticin biosynthesis employs a new strategy for starter unit generation.

Abraham J Waldman1, Emily P Balskus.   

Abstract

Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this enzymatic activity within natural product biosynthesis.

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Year:  2014        PMID： 24383813      PMCID： PMC3965344          DOI： 10.1021/ol403714g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  27 in total

1.  In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase.

Authors:  E S Meadows; C Khosla
Journal:  Biochemistry       Date:  2001-12-11       Impact factor: 3.162

Review 2.  Biosynthesis and attachment of novel bacterial polyketide synthase starter units.

Authors:  Bradley S Moore; Christian Hertweck
Journal:  Nat Prod Rep       Date:  2002-02       Impact factor: 13.423

3.  Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.

Authors:  L E Quadri; P H Weinreb; M Lei; M M Nakano; P Zuber; C T Walsh
Journal:  Biochemistry       Date:  1998-02-10       Impact factor: 3.162

4.  Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase.

Authors:  C W Carreras; C Khosla
Journal:  Biochemistry       Date:  1998-02-24       Impact factor: 3.162

5.  The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide.

Authors:  W Bao; P J Sheldon; E Wendt-Pienkowski; C R Hutchinson
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

6.  Cloning and heterologous expression of genes from the kinamycin biosynthetic pathway of Streptomyces murayamaensis.

Authors:  S J Gould; S T Hong; J R Carney
Journal:  J Antibiot (Tokyo)       Date:  1998-01       Impact factor: 2.649

7.  Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.

Authors:  M J Bibb; D H Sherman; S Omura; D A Hopwood
Journal:  Gene       Date:  1994-05-03       Impact factor: 3.688

8.  Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.

Authors:  Yi Tang; Taek Soon Lee; Seiji Kobayashi; Chaitan Khosla
Journal:  Biochemistry       Date:  2003-06-03       Impact factor: 3.162

9.  Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant.

Authors:  W P Revill; M J Bibb; D A Hopwood
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

10.  Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis.

Authors:  R G Summers; A Ali; B Shen; W A Wessel; C R Hutchinson
Journal:  Biochemistry       Date:  1995-07-25       Impact factor: 3.162
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  11 in total

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Authors:  David R Jackson; Stephanie S Tu; MyChi Nguyen; Jesus F Barajas; Andrew J Schaub; Daniel Krug; Dominik Pistorius; Ray Luo; Rolf Müller; Shiou-Chuan Tsai
Journal:  ACS Chem Biol       Date:  2015-11-03       Impact factor: 5.100

Review 2.  The re-emergence of natural products for drug discovery in the genomics era.

Authors:  Alan L Harvey; RuAngelie Edrada-Ebel; Ronald J Quinn
Journal:  Nat Rev Drug Discov       Date:  2015-01-23       Impact factor: 84.694

Review 3.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

4.  Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica.

Authors:  Jeffrey E Janso; Brad A Haltli; Alessandra S Eustáquio; Kerry Kulowski; Abraham J Waldman; Li Zha; Hitomi Nakamura; Valerie S Bernan; Haiyin He; Guy T Carter; Frank E Koehn; Emily P Balskus
Journal:  Tetrahedron       Date:  2014-07-08       Impact factor: 2.457

Review 5.  The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.

Authors:  Paul R Jensen; Bradley S Moore; William Fenical
Journal:  Nat Prod Rep       Date:  2015-05       Impact factor: 13.423

6.  Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments.

Authors:  Feng Li; Zhenjian Lin; Joshua P Torres; Eric A Hill; Dehai Li; Craig A Townsend; Eric W Schmidt
Journal:  J Am Chem Soc       Date:  2022-05-19       Impact factor: 16.383

Review 7.  Recent advances in the biosynthesis of unusual polyketide synthase substrates.

Authors:  Lauren Ray; Bradley S Moore
Journal:  Nat Prod Rep       Date:  2016-02       Impact factor: 13.423

8.  Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative.

Authors:  Raúl García Salcedo; Carlos Olano; Cristina Gómez; Rogelio Fernández; Alfredo F Braña; Carmen Méndez; Fernando de la Calle; José A Salas
Journal:  Microb Cell Fact       Date:  2016-02-22       Impact factor: 5.328

Review 9.  New insights into bacterial type II polyketide biosynthesis.

Authors:  Zhuan Zhang; Hai-Xue Pan; Gong-Li Tang
Journal:  F1000Res       Date:  2017-02-21

10.  Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis.

Authors:  Yi Zou; Wei Xu; Yuta Tsunematsu; Mancheng Tang; Kenji Watanabe; Yi Tang
Journal:  Org Lett       Date:  2014-12-10       Impact factor: 6.005
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