Literature DB >> 17060944

Polycomb silencers control cell fate, development and cancer.

Anke Sparmann1, Maarten van Lohuizen.   

Abstract

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17060944     DOI： 10.1038/nrc1991

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  594 in total

Review 1.  The role of epigenetic regulation in stem cell and cancer biology.

Authors:  Lilian E van Vlerken; Elaine M Hurt; Robert E Hollingsworth
Journal:  J Mol Med (Berl)       Date:  2012-06-02       Impact factor: 4.599

2.  BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair.

Authors:  Ismail Hassan Ismail; Christi Andrin; Darin McDonald; Michael J Hendzel
Journal:  J Cell Biol       Date:  2010-10-04       Impact factor: 10.539

3.  Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma.

Authors:  Cheng Wang; Xiqiang Liu; Zujian Chen; Hongzhang Huang; Yi Jin; Antonia Kolokythas; Anxun Wang; Yang Dai; David T W Wong; Xiaofeng Zhou
Journal:  Mol Carcinog       Date:  2011-12-07       Impact factor: 4.784

Review 4.  Extra sex combs, chromatin, and cancer: exploring epigenetic regulation and tumorigenesis in Drosophila.

Authors:  Can Zhang; Bo Liu; Guangyao Li; Lei Zhou
Journal:  J Genet Genomics       Date:  2011-09-24       Impact factor: 4.275

5.  Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.

Authors:  Tianyun Jiang; Brendan J Collins; Ning Jin; David N Watkins; Malcolm V Brock; William Matsui; Barry D Nelkin; Douglas W Ball
Journal:  Cancer Res       Date:  2009-01-27       Impact factor: 12.701

6.  A genetic screen identifies novel polycomb group genes in Drosophila.

Authors:  Andrés Gaytán de Ayala Alonso; Luis Gutiérrez; Cornelia Fritsch; Bernadett Papp; Dirk Beuchle; Jürg Müller
Journal:  Genetics       Date:  2007-08       Impact factor: 4.562

7.  EZH2-specific microRNA-98 inhibits human ovarian cancer stem cell proliferation via regulating the pRb-E2F pathway.

Authors:  Te Liu; Lengchen Hou; Yongyi Huang
Journal:  Tumour Biol       Date:  2014-04-27

Review 8.  EZH2: not EZHY (easy) to deal.

Authors:  Gauri Deb; Anup Kumar Singh; Sanjay Gupta
Journal:  Mol Cancer Res       Date:  2014-02-13       Impact factor: 5.852

9.  Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

Authors:  Yan Liu; Fan Liu; Hao Yu; Xinyang Zhao; Goro Sashida; Anthony Deblasio; Michael Harr; Qing-Bai She; Zhenbang Chen; Hui-Kuan Lin; Silvana Di Giandomenico; Shannon E Elf; Youyang Yang; Yasuhiko Miyata; Gang Huang; Silvia Menendez; Ingo K Mellinghoff; Neal Rosen; Pier Paolo Pandolfi; Cyrus V Hedvat; Stephen D Nimer
Journal:  Sci Signal       Date:  2012-10-23       Impact factor: 8.192

Review 10.  Epigenetic Mechanisms and Events in Gastric Cancer-Emerging Novel Biomarkers.

Authors:  Hasan Raza Kazmi; Soni Kumari; Satendra Tiwari; A Khanna; Gopeshwar Narayan
Journal:  Pathol Oncol Res       Date:  2018-03-19       Impact factor: 3.201
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.