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Literature DB >> 24382385

Characterizing DNA methylation alterations from The Cancer Genome Atlas.

Abstract

The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.

Entities: Disease Species

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Year: 2014 PMID： 24382385 PMCID： PMC3871233 DOI： 10.1172/JCI69740

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

88 in total

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Journal: Nucleic Acids Res Date: 2005-12-02 Impact factor: 16.971

76 in total

Review 1. Patterns of Chromosomal Aberrations in Solid Tumors.

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Journal: Hum Mol Genet Date: 2015-07-28 Impact factor: 6.150

3. DNA methylation differentially regulates cytokine secretion in gingival epithelia in response to bacterial challenges.

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Journal: Pathog Dis Date: 2014-12-04 Impact factor: 3.166

4. MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution.

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Journal: J Mol Cell Biol Date: 2015-06-15 Impact factor: 6.216

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Journal: J Cancer Res Clin Oncol Date: 2018-07-10 Impact factor: 4.553

6. Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7.

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Journal: Cancer Res Date: 2016-01-12 Impact factor: 12.701