Ioan Sporea1, Simona Bota2, Oana Gradinaru-Taşcău3, Roxana Sirli4, Alina Popescu5, Ana Jurchiş6. 1. Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. Electronic address: isporea@umft.ro. 2. Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. Electronic address: bota_simona1982@yahoo.com. 3. Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. Electronic address: bluonmyown@yahoo.com. 4. Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. Electronic address: roxanasirli@gmail.com. 5. Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. Electronic address: alinamircea.popescu@gmail.com. 6. Department of Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. Electronic address: ana.jurchis@yahoo.com.
Abstract
INTRODUCTION: To identify liver stiffness (LS) cut-off values assessed by means of 2D-Shear Wave Elastography (2D-SWE) for predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method. METHODS: Our prospective study included 383 consecutive subjects, with or without hepatopathies, in which LS was evaluated by means of TE and 2D-SWE. To discriminate between various stages of fibrosis by TE we used the following LS cut-offs (kPa): F1-6, F2-7.2, F3-9.6 and F4-14.5. RESULTS: The rate of reliable LS measurements was similar for TE and 2D-SWE: 73.9% vs. 79.9%, p=0.06. Older age and higher BMI were associated for both TE and 2D-SWE with the impossibility to obtain reliable LS measurements. Reliable LS measurements by both elastographic methods were obtained in 65.2% of patients. A significant correlation was found between TE and 2D-SWE measurements (r=0.68). The best LS cut-off values assessed by 2D-SWE for predicting different stages of liver fibrosis were: F≥1: >7.1 kPa (AUROC=0.825); F≥2: >7.8 kPa (AUROC=0.859); F≥3: >8 kPa (AUROC=0.897) and for F=4: >11.5 kPa (AUROC=0.914). CONCLUSIONS: 2D-SWE is a reliable method for the non-invasive evaluation of liver fibrosis, considering TE as the reference method. The accuracy of 2D-SWE measurements increased with the severity of liver fibrosis.
INTRODUCTION: To identify liver stiffness (LS) cut-off values assessed by means of 2D-Shear Wave Elastography (2D-SWE) for predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method. METHODS: Our prospective study included 383 consecutive subjects, with or without hepatopathies, in which LS was evaluated by means of TE and 2D-SWE. To discriminate between various stages of fibrosis by TE we used the following LS cut-offs (kPa): F1-6, F2-7.2, F3-9.6 and F4-14.5. RESULTS: The rate of reliable LS measurements was similar for TE and 2D-SWE: 73.9% vs. 79.9%, p=0.06. Older age and higher BMI were associated for both TE and 2D-SWE with the impossibility to obtain reliable LS measurements. Reliable LS measurements by both elastographic methods were obtained in 65.2% of patients. A significant correlation was found between TE and 2D-SWE measurements (r=0.68). The best LS cut-off values assessed by 2D-SWE for predicting different stages of liver fibrosis were: F≥1: >7.1 kPa (AUROC=0.825); F≥2: >7.8 kPa (AUROC=0.859); F≥3: >8 kPa (AUROC=0.897) and for F=4: >11.5 kPa (AUROC=0.914). CONCLUSIONS: 2D-SWE is a reliable method for the non-invasive evaluation of liver fibrosis, considering TE as the reference method. The accuracy of 2D-SWE measurements increased with the severity of liver fibrosis.
Authors: Manish Dhyani; Joseph R Grajo; Atul K Bhan; Kathleen Corey; Raymond Chung; Anthony E Samir Journal: Ultrasound Med Biol Date: 2017-03-22 Impact factor: 2.998
Authors: Jeanne M Horowitz; Sudhakar K Venkatesh; Richard L Ehman; Kartik Jhaveri; Patrick Kamath; Michael A Ohliger; Anthony E Samir; Alvin C Silva; Bachir Taouli; Michael S Torbenson; Michael L Wells; Benjamin Yeh; Frank H Miller Journal: Abdom Radiol (NY) Date: 2017-08