Literature DB >> 24380019

Small Airway Targeted Therapy in Pediatric Asthma: Are We There Yet?

Hengameh H Raissy1, Kathryn Blake2.   

Abstract

Asthma is characterized by inflammation of proximal and distal airways. As new formulations of extrafine aerosol particles have become available, targeting small airways for the management of asthma has been investigated. As new studies attempt to explore the correlation between small airway dysfunction and clinical outcomes in asthma, well-designed clinical trials are needed to compare targeted and standard therapy for asthma management especially in pediatric patients.

Entities:  

Year:  2013        PMID： 24380019      PMCID： PMC3869414          DOI： 10.1089/ped.2013.0304

Source DB:  PubMed          Journal:  Pediatr Allergy Immunol Pulmonol        ISSN： 2151-321X            Impact factor:   1.349


  16 in total

Review 1.  Update on the roles of distal airways in asthma.

Authors:  P-R Burgel; J de Blic; P Chanez; C Delacourt; P Devillier; A Didier; J-C Dubus; I Frachon; G Garcia; M Humbert; F Laurent; R Louis; A Magnan; B Mahut; T Perez; N Roche; I Tillie-Leblond; M Tunon de Lara; D Dusser
Journal:  Eur Respir Rev       Date:  2009-06

Review 2.  Factors that affect the efficacy of inhaled corticosteroids for infants and young children.

Authors:  Israel Amirav; Michael T Newhouse; Stefan Minocchieri; Jose A Castro-Rodriguez; Karen G Schüepp
Journal:  J Allergy Clin Immunol       Date:  2010-03-24       Impact factor: 10.793

3.  Air trapping in mild and moderate asthma: effect of inhaled corticosteroids.

Authors:  José-Manuel Tunon-de-Lara; François Laurent; Violaine Giraud; Thierry Perez; Bernard Aguilaniu; Houari Meziane; Armelle Basset-Merle; Pascal Chanez
Journal:  J Allergy Clin Immunol       Date:  2007-01-03       Impact factor: 10.793

4.  Effects of asthma on pulmonary function in children. A longitudinal population-based study.

Authors:  S T Weiss; T D Tosteson; M R Segal; I B Tager; S Redline; F E Speizer
Journal:  Am Rev Respir Dis       Date:  1992-01

Review 5.  Targeting small airways, a step further in asthma management.

Authors:  Leif Bjermer
Journal:  Clin Respir J       Date:  2011-05-10       Impact factor: 2.570

6.  Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography.

Authors:  J G Goldin; D P Tashkin; E C Kleerup; L E Greaser; U M Haywood; J W Sayre; M D Simmons; M Suttorp; G L Colice; J A Vanden Burgt; D R Aberle
Journal:  J Allergy Clin Immunol       Date:  1999-12       Impact factor: 10.793

7.  Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children.

Authors:  Yixin Shi; Anna S Aledia; Stanley P Galant; Steven C George
Journal:  J Allergy Clin Immunol       Date:  2012-11-10       Impact factor: 10.793

Review 8.  The importance and features of the distal airways in children and adults.

Authors:  Erwin W Gelfand; Monica Kraft
Journal:  J Allergy Clin Immunol       Date:  2009-12       Impact factor: 10.793

9.  The utility of forced expiratory flow between 25% and 75% of vital capacity in predicting childhood asthma morbidity and severity.

Authors:  Devika R Rao; Jonathan M Gaffin; Sachin N Baxi; William J Sheehan; Elaine B Hoffman; Wanda Phipatanakul
Journal:  J Asthma       Date:  2012-06-28       Impact factor: 2.515

10.  Comparison of the anti-inflammatory effects of extra-fine hydrofluoroalkane-beclomethasone vs fluticasone dry powder inhaler on exhaled inflammatory markers in childhood asthma.

Authors:  Charlotte M H H T Robroeks; Kim D G van de Kant; Dillys van Vliet; Arnold D Kester; Han J E Hendriks; Jan G M C Damoiseaux; Will K W H Wodzig; Ger T Rijkers; Edward Dompeling; Quirijn Jöbsis
Journal:  Ann Allergy Asthma Immunol       Date:  2008-06       Impact factor: 6.347
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