OBJECTIVE: The aim of the present study was to evaluate the levels and correlation of human S100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and without type 2 diabetes mellitus (DM). MATERIALS AND METHODS: A total of 44 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects, group 2 consisted of 17 CP subjects and group 3 had 17 type 2 DM subjects with CP. GCF and serum levels of human S100A12 and hs-CRP were quantified using enzyme-linked immunosorbent assay and immunoturbidimetric analysis, respectively. The clinical outcomes evaluated were gingival index, probing depth and clinical attachment level and the correlations of the two inflammatory mediators with clinical parameters were evaluated. RESULTS: Both human S100A12 and hs-CRP levels increased from group 1 to group 2 to group 3. The GCF and serum values of both these inflammatory mediators correlated positively with each other and with the periodontal parameters evaluated (p < 0.05). CONCLUSION: Human S100A12 and hs-CRP can be considered as possible GCF and serum markers of inflammatory activity in CP and DM.
OBJECTIVE: The aim of the present study was to evaluate the levels and correlation of humanS100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and without type 2 diabetes mellitus (DM). MATERIALS AND METHODS: A total of 44 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects, group 2 consisted of 17 CP subjects and group 3 had 17 type 2 DM subjects with CP. GCF and serum levels of humanS100A12 and hs-CRP were quantified using enzyme-linked immunosorbent assay and immunoturbidimetric analysis, respectively. The clinical outcomes evaluated were gingival index, probing depth and clinical attachment level and the correlations of the two inflammatory mediators with clinical parameters were evaluated. RESULTS: Both humanS100A12 and hs-CRP levels increased from group 1 to group 2 to group 3. The GCF and serum values of both these inflammatory mediators correlated positively with each other and with the periodontal parameters evaluated (p < 0.05). CONCLUSION:HumanS100A12 and hs-CRP can be considered as possible GCF and serum markers of inflammatory activity in CP and DM.
Authors: M A Hofmann; S Drury; C Fu; W Qu; A Taguchi; Y Lu; C Avila; N Kambham; A Bierhaus; P Nawroth; M F Neurath; T Slattery; D Beach; J McClary; M Nagashima; J Morser; D Stern; A M Schmidt Journal: Cell Date: 1999-06-25 Impact factor: 41.582
Authors: A R Pradeep; N M Raghavendra; Anuj Sharma; Swati Pradeep Patel; Arjun Raju; Rahul Kathariya; Nishanth S Rao; Savitha B Naik Journal: J Periodontol Date: 2011-10-03 Impact factor: 6.993
Authors: Zheng Yang; Wei Xing Yan; Hong Cai; Nicodemus Tedla; Chris Armishaw; Nick Di Girolamo; Hong Wei Wang; Taline Hampartzoumian; Jodie L Simpson; Peter G Gibson; John Hunt; Prue Hart; J Margaret Hughes; Michael A Perry; Paul F Alewood; Carolyn L Geczy Journal: J Allergy Clin Immunol Date: 2006-10-06 Impact factor: 10.793