| Literature DB >> 10399917 |
M A Hofmann1, S Drury, C Fu, W Qu, A Taguchi, Y Lu, C Avila, N Kambham, A Bierhaus, P Nawroth, M F Neurath, T Slattery, D Beach, J McClary, M Nagashima, J Morser, D Stern, A M Schmidt.
Abstract
S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathways and expression of inflammatory gene mediators. These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury.Entities:
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Year: 1999 PMID： 10399917 DOI： 10.1016/s0092-8674(00)80801-6
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582