INTRODUCTION: The Merendino (MER) procedure has been evaluated as an alternative to transthoracic esophageal resection (TER) for early stage Barrett's carcinoma. Apart from reducing morbidity and mortality, improvements concerning postoperative health-related quality of life (HRQL) have been postulated. The aim of our study was to compare HRQL between these procedures. MATERIALS AND METHODS: Between July 2000 and July 2007, 117 patients with early Barrett's carcinoma underwent surgery. Patients with tumor recurrence were excluded from the study. HRQL was assessed 1 and 2 years after surgery using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC-QLQ-C30) and the QLQ-OES18 module. Patients recently diagnosed with early Barrett's carcinoma served as controls. Symptoms that showed a difference of more than ten between the control and the study groups were considered clinically relevant and were tested for significant differences between the study groups using the Mann-Whitney U test (p < 0.05). RESULTS: The response rates for the questionnaires ranged between 70 and 93 %. In the MER group, more items reflected a clinical relevant impairment of HRQL than in the TER group. Significant complaints in the MER group included nausea/vomiting, appetite loss, local pain, difficulties with social eating, and choking. Moreover, we found a significant restriction concerning global health and emotional and social functioning in this group 1 year after surgery. 2 years postoperatively, hardly any differences between the operative techniques could be detected. The only symptom in favor of the MER procedure was a better dysphagia score postoperatively. CONCLUSION: Our study suggests that MER procedure is not superior to subtotal esophagectomy with regard to HRQL.
INTRODUCTION: The Merendino (MER) procedure has been evaluated as an alternative to transthoracic esophageal resection (TER) for early stage Barrett's carcinoma. Apart from reducing morbidity and mortality, improvements concerning postoperative health-related quality of life (HRQL) have been postulated. The aim of our study was to compare HRQL between these procedures. MATERIALS AND METHODS: Between July 2000 and July 2007, 117 patients with early Barrett's carcinoma underwent surgery. Patients with tumor recurrence were excluded from the study. HRQL was assessed 1 and 2 years after surgery using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC-QLQ-C30) and the QLQ-OES18 module. Patients recently diagnosed with early Barrett's carcinoma served as controls. Symptoms that showed a difference of more than ten between the control and the study groups were considered clinically relevant and were tested for significant differences between the study groups using the Mann-Whitney U test (p < 0.05). RESULTS: The response rates for the questionnaires ranged between 70 and 93 %. In the MER group, more items reflected a clinical relevant impairment of HRQL than in the TER group. Significant complaints in the MER group included nausea/vomiting, appetite loss, local pain, difficulties with social eating, and choking. Moreover, we found a significant restriction concerning global health and emotional and social functioning in this group 1 year after surgery. 2 years postoperatively, hardly any differences between the operative techniques could be detected. The only symptom in favor of the MER procedure was a better dysphagia score postoperatively. CONCLUSION: Our study suggests that MER procedure is not superior to subtotal esophagectomy with regard to HRQL.
Authors: Christian A Gutschow; Arnulf H Hölscher; Jessica Leers; Hans Fuchs; Marc Bludau; Klaus L Prenzel; E Bollschweiler; Wolfgang Schröder Journal: Langenbecks Arch Surg Date: 2012-06-04 Impact factor: 3.445
Authors: Ahmedin Jemal; Taylor Murray; Elizabeth Ward; Alicia Samuels; Ram C Tiwari; Asma Ghafoor; Eric J Feuer; Michael J Thun Journal: CA Cancer J Clin Date: 2005 Jan-Feb Impact factor: 508.702
Authors: Lorenza Alvarez Herrero; Frederike G I van Vilsteren; Roos E Pouw; Fiebo J W ten Kate; Mike Visser; Cornelis A Seldenrijk; Mark I van Berge Henegouwen; Paul Fockens; Bas L A M Weusten; Jaques J G H M Bergman Journal: Gastrointest Endosc Date: 2011-02-02 Impact factor: 9.427
Authors: H A Gaissert; D J Mathisen; H C Grillo; R A Malt; J C Wain; A C Moncure; J H Kim; P R Mueller; R DeAngelis; L W Ottinger Journal: J Thorac Cardiovasc Surg Date: 1993-11 Impact factor: 5.209
Authors: Thomas Haist; Markus Mann; Christina Oetzmann von Sochaczewski; Michael Pauthner; Annette Fisseler-Eckhoff; Dietmar Lorenz Journal: World J Surg Date: 2017-10 Impact factor: 3.352
Authors: Kyriakos Neofytou; Mafalda Costa Neves; Alexandros Giakoustidis; Charlotte Benson; Satvinder Mudan Journal: Case Rep Oncol Med Date: 2015-05-05
Authors: Apostolos Analatos; Mats Lindblad; Ioannis Rouvelas; Peter Elbe; Lars Lundell; Magnus Nilsson; Andrianos Tsekrekos; Jon A Tsai Journal: BMC Surg Date: 2018-08-30 Impact factor: 2.102