R Scott Mackin1, J Craig Nelson2, Kevin Delucchi2, Patrick Raue3, Amy Byers4, Deborah Barnes4, Derek D Satre5, Kristine Yaffe4, George S Alexopoulos3, Patricia A Arean2. 1. Department of Psychiatry, University of California, San Francisco, San Francisco, CA; Center for Imaging of Neurodegenerative Disease, San Francisco, CA; Veterans Administration Medical Center, San Francisco, CA. Electronic address: scottm@lppi.ucsf.edu. 2. Department of Psychiatry, University of California, San Francisco, San Francisco, CA. 3. Department of Psychiatry, Weill Cornell Medical College, New York, NY. 4. Department of Psychiatry, University of California, San Francisco, San Francisco, CA; Veterans Administration Medical Center, San Francisco, CA. 5. Department of Psychiatry, University of California, San Francisco, San Francisco, CA; Kaiser Permanente Division of Research, Oakland, CA.
Abstract
OBJECTIVE: The purpose of this study was to determine the impact of psychotherapy on cognitive functioning in older adults with late-life depression (LLD) and executive dysfunction. METHODS:Two hundred twenty-one adults aged 60 years and older participated in a randomized clinical trial comparing the efficacy of Problem Solving Therapy (PST) and Supportive Therapy (ST) for LLD. Cognitive performance on seven tests of executive functioning, verbal learning, and memory was evaluated at baseline, after 12 weeks of treatment, and at 24 weeks after the completion of treatment. RESULTS: Performance on a measure of executive functioning with a significant information processing speed component (Stroop Color and Word Test) improved after treatment, F (1, 312) = 8.50, p = 0.002, and improved performance was associated with a reduction in depressive symptoms but not treatment type. Performance on other measures of executive functioning, verbal learning, and memory did not change significantly after 12 weeks of psychotherapy treatment. CONCLUSION: Our results suggest that improvements in cognitive functioning after psychotherapy treatment for depression in older adults with executive dysfunction are likely focal and not distributed across all cognitive domains. Although previous analyses reported that PST was superior to ST in the treatment of depression, this analysis indicated no difference between the two treatments with regard to improvements in cognitive functioning. Published by Elsevier Inc.
RCT Entities:
OBJECTIVE: The purpose of this study was to determine the impact of psychotherapy on cognitive functioning in older adults with late-life depression (LLD) and executive dysfunction. METHODS: Two hundred twenty-one adults aged 60 years and older participated in a randomized clinical trial comparing the efficacy of Problem Solving Therapy (PST) and Supportive Therapy (ST) for LLD. Cognitive performance on seven tests of executive functioning, verbal learning, and memory was evaluated at baseline, after 12 weeks of treatment, and at 24 weeks after the completion of treatment. RESULTS: Performance on a measure of executive functioning with a significant information processing speed component (Stroop Color and Word Test) improved after treatment, F (1, 312) = 8.50, p = 0.002, and improved performance was associated with a reduction in depressive symptoms but not treatment type. Performance on other measures of executive functioning, verbal learning, and memory did not change significantly after 12 weeks of psychotherapy treatment. CONCLUSION: Our results suggest that improvements in cognitive functioning after psychotherapy treatment for depression in older adults with executive dysfunction are likely focal and not distributed across all cognitive domains. Although previous analyses reported that PST was superior to ST in the treatment of depression, this analysis indicated no difference between the two treatments with regard to improvements in cognitive functioning. Published by Elsevier Inc.
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