BACKGROUND: To analyze and compare dose distribution homogeneity in selected points (especially in the chest wall region) for patients irradiated with two different TBI techniques to achieve a uniform total dose (excluding lungs area) specified in the range of 11.4-14.0 Gy. MATERIAL AND METHODS: From August 2000 to December 2009, a group of 158 patients was treated by the use of 15 MV photon irradiation consisting of six fractions: four opposed lateral and two anterior-posterior/posterior-anterior (AP/PA). Patients were irradiated with the fraction dose of 2 Gy twice a day for 3 consecutive days. The prescribed dose to PC point (specified at intersection of the beam axis with the mid-plane of the patient irradiated laterally) was 12 Gy. Since January 2010 until closing the study, another group of 50 patients was treated according to a modified protocol. The treatment was carried out in six lateral fractions only, twice a day, for three following days and a lateral lung shield was used for a part of total irradiation time. The measurements of doses in 20 selected points of patient's body were carried out by means of MOSFET detectors. RESULTS: The modified TBI technique allows to achieve an expected homogenous dose in the points of interest similar to that obtained by using the initial protocol. The calculated and measured in vivo doses met the specified range of 11.4-14 Gy for both applied TBI protocols. CONCLUSIONS: Our results indicate that for all patients the homogenous dose distribution in the specified range was achieved.
BACKGROUND: To analyze and compare dose distribution homogeneity in selected points (especially in the chest wall region) for patients irradiated with two different TBI techniques to achieve a uniform total dose (excluding lungs area) specified in the range of 11.4-14.0 Gy. MATERIAL AND METHODS: From August 2000 to December 2009, a group of 158 patients was treated by the use of 15 MV photon irradiation consisting of six fractions: four opposed lateral and two anterior-posterior/posterior-anterior (AP/PA). Patients were irradiated with the fraction dose of 2 Gy twice a day for 3 consecutive days. The prescribed dose to PC point (specified at intersection of the beam axis with the mid-plane of the patient irradiated laterally) was 12 Gy. Since January 2010 until closing the study, another group of 50 patients was treated according to a modified protocol. The treatment was carried out in six lateral fractions only, twice a day, for three following days and a lateral lung shield was used for a part of total irradiation time. The measurements of doses in 20 selected points of patient's body were carried out by means of MOSFET detectors. RESULTS: The modified TBI technique allows to achieve an expected homogenous dose in the points of interest similar to that obtained by using the initial protocol. The calculated and measured in vivo doses met the specified range of 11.4-14 Gy for both applied TBI protocols. CONCLUSIONS: Our results indicate that for all patients the homogenous dose distribution in the specified range was achieved.
Authors: Ute Hegenbart; Dietger Niederwieser; Brenda M Sandmaier; Michael B Maris; Judith A Shizuru; Hildegard Greinix; Catherine Cordonnier; Bernard Rio; Alois Gratwohl; Thoralf Lange; Haifa Al-Ali; Barry Storer; David Maloney; Peter McSweeney; Thomas Chauncey; Ed Agura; Benedetto Bruno; Richard T Maziarz; Finn Petersen; Rainer Storb Journal: J Clin Oncol Date: 2005-12-12 Impact factor: 44.544
Authors: J A Peñagarícano; M Chao; F Van Rhee; E G Moros; P M Corry; V Ratanatharathorn Journal: Bone Marrow Transplant Date: 2010-10-11 Impact factor: 5.483
Authors: Agustina Mariana Portu; Andrés Eugenio Rossini; Mario Alberto Gadan; Omar Alberto Bernaola; Silvia Inés Thorp; Paula Curotto; Emiliano César Cayetano Pozzi; Rómulo Luis Cabrini; Gisela Saint Martin Journal: Rep Pract Oncol Radiother Date: 2014-11-04
Authors: Andreas Springer; Josef Hammer; Erwin Winkler; Christine Track; Roswitha Huppert; Alexandra Böhm; Hedwig Kasparu; Ansgar Weltermann; Gregor Aschauer; Andreas L Petzer; Ernst Putz; Alexander Altenburger; Rainer Gruber; Karin Moser; Karin Wiesauer; Hans Geinitz Journal: Radiat Oncol Date: 2016-03-22 Impact factor: 3.481