BACKGROUND: Abnormal task-related activation in primary motor cortices (M1) has been consistently found in functional imaging studies of subcortical stroke. Whether the abnormal activations are associated with neuronal alterations in the same or homologous area is not known. OBJECTIVE: Our goal was to establish the relationships between M1 measures of motor-task-related activation and a neuronal marker, N-acetylaspartate (NAA), in patients with severe to mild hemiparesis. METHODS: A total of 18 survivors of an ischemic subcortical stroke (confirmed on T2-weighted images) at more than six months post-onset and 16 age- and sex-matched right-handed healthy controls underwent functional MRI during a handgrip task (impaired hand in patients, dominant hand in controls) and proton magnetic resonance spectroscopy ((1)H-MRS) imaging. Spatial extent and magnitude of blood oxygen level-dependent response (or activation) and NAA levels were measured in each M1. Relationships between activation and NAA were determined. RESULTS: Compared with controls, patients had a greater extent of contralesional (ipsilateral to impaired hand, P < .001) activation and a higher magnitude of activation and lower NAA in both ipsilesional (P = .008 and P < .001, respectively) and contralesional (P < .0001, P < .05) M1. There were significant negative correlations between extent of activation and NAA in each M1 (P = .02) and a trend between contralesional activation and ipsilesional NAA (P = .08) in patients but not in controls. CONCLUSIONS: Our results suggest that after stroke greater neuronal recruitment could be a compensatory response to lower neuronal metabolism. Thus, dual-modality imaging may be a powerful tool for providing complementary probes of post-stroke brain reorganization.
BACKGROUND: Abnormal task-related activation in primary motor cortices (M1) has been consistently found in functional imaging studies of subcortical stroke. Whether the abnormal activations are associated with neuronal alterations in the same or homologous area is not known. OBJECTIVE: Our goal was to establish the relationships between M1 measures of motor-task-related activation and a neuronal marker, N-acetylaspartate (NAA), in patients with severe to mild hemiparesis. METHODS: A total of 18 survivors of an ischemic subcortical stroke (confirmed on T2-weighted images) at more than six months post-onset and 16 age- and sex-matched right-handed healthy controls underwent functional MRI during a handgrip task (impaired hand in patients, dominant hand in controls) and proton magnetic resonance spectroscopy ((1)H-MRS) imaging. Spatial extent and magnitude of blood oxygen level-dependent response (or activation) and NAA levels were measured in each M1. Relationships between activation and NAA were determined. RESULTS: Compared with controls, patients had a greater extent of contralesional (ipsilateral to impaired hand, P < .001) activation and a higher magnitude of activation and lower NAA in both ipsilesional (P = .008 and P < .001, respectively) and contralesional (P < .0001, P < .05) M1. There were significant negative correlations between extent of activation and NAA in each M1 (P = .02) and a trend between contralesional activation and ipsilesional NAA (P = .08) in patients but not in controls. CONCLUSIONS: Our results suggest that after stroke greater neuronal recruitment could be a compensatory response to lower neuronal metabolism. Thus, dual-modality imaging may be a powerful tool for providing complementary probes of post-stroke brain reorganization.
Authors: Heidi Johansen-Berg; Matthew F S Rushworth; Marko D Bogdanovic; Udo Kischka; Sunil Wimalaratna; Paul M Matthews Journal: Proc Natl Acad Sci U S A Date: 2002-10-10 Impact factor: 11.205
Authors: S C Cramer; G Nelles; R R Benson; J D Kaplan; R A Parker; K K Kwong; D N Kennedy; S P Finklestein; B R Rosen Journal: Stroke Date: 1997-12 Impact factor: 7.914
Authors: Carmen M Cirstea; William M Brooks; Sorin C Craciunas; Elena A Popescu; In-Young Choi; Phil Lee; Ali Bani-Ahmed; Hung-Wen Yeh; Cary R Savage; Leonardo G Cohen; Randolph J Nudo Journal: Stroke Date: 2011-02-17 Impact factor: 7.914
Authors: Numa Dancause; Scott Barbay; Shawn B Frost; Erik J Plautz; Daofen Chen; Elena V Zoubina; Ann M Stowe; Randolph J Nudo Journal: J Neurosci Date: 2005-11-02 Impact factor: 6.167
Authors: Carmen M Cirstea; Phil Lee; Sorin C Craciunas; In-Young Choi; Joseph E Burris; Randolph J Nudo Journal: Am J Phys Med Rehabil Date: 2018-01 Impact factor: 2.159
Authors: Carmen M Cirstea; In-Young Choi; Phil Lee; Huiling Peng; Christina L Kaufman; Scott H Frey Journal: J Neurophysiol Date: 2017-02-08 Impact factor: 2.714
Authors: Jennifer K Ferris; Jason L Neva; Irene M Vavasour; Kaitlin J Attard; Brian Greeley; Kathryn S Hayward; Katie P Wadden; Alex L MacKay; Lara A Boyd Journal: Hum Brain Mapp Date: 2021-05-03 Impact factor: 5.038
Authors: Alexander A Brown; Bradley J Ferguson; Vovanti Jones; Bruce E Green; Justin D Pearre; Ifeoma A Anunoby; David Q Beversdorf; Richard J Barohn; Carmen M Cirstea Journal: Front Artif Intell Date: 2022-07-07
Authors: Lorena Cristina Alvarez Sartor; Gustavo José Luvizutto; Juli Thomaz de Souza; Evelin Roberta Silva Dalle Molle; Gabriel Pinheiro Modolo; Taís Regina da Silva; Robson Aparecido Prudente; Priscila Watson Ribeiro; Rafael Dalle Molle da Costa; Letícia Cláudia de Oliveira Antunes; Natália Cristina Ferreira; Silméia Garcia Zanati Bazan; Fernanda Cristina Winckler; Hélio Rubens de Carvalho Nunes; Marcos Ferreira Minicucci; Rodrigo Bazan Journal: Rehabil Res Pract Date: 2020-02-03