| Literature DB >> 24375946 |
Kang Liang1, Georgina K Such, Angus P R Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso.
Abstract
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.Entities:
Keywords: biomaterials; drug delivery; layer-by-layer; nanotechnology; polymer capsules
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Year: 2013 PMID： 24375946 DOI： 10.1002/adma.201305144
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849