Literature DB >> 2437238

Functional and antigenic properties of complement receptor type 2, CR2.

K Mitomo, T Fujita, K Iida.   

Abstract

This is the first report demonstrating that C3d receptor (CR2) has functional activity in regulating complement cascade. Purified CR2 was examined for its cofactor activity in factor I-mediated cleavage of membrane-bound iC3b. CR2 plus C3b inactivator (I) released C3c from EA 125I-iC3b, and the release was inhibited when CR2 was preincubated with OKB7 monoclonal anti-CR2. Furthermore, immunoelectroblotting analysis showed crossreactivity of CR2 with 57H anti-CR1. These results indicate that CR2 has functional and antigenic similarity to CR1, thus providing a supporting evidence for placement of CR2 as a member of the recently defined gene family of C3- and C4-regulatory proteins composed of CR1, C4-binding protein, and factor H.

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Year:  1987        PMID： 2437238      PMCID： PMC2188314          DOI： 10.1084/jem.165.5.1424

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  Binding of monoclonal antibody to the Epstein Barr virus (EBV)/CR2 receptor induces activation and differentiation of human B lymphocytes.

Authors:  G R Nemerow; M E McNaughton; N R Cooper
Journal:  J Immunol       Date:  1985-11       Impact factor: 5.422

2.  Purification of the B lymphocyte receptor for the C3d fragment of complement and the Epstein-Barr virus by monoclonal antibody affinity chromatography, and assessment of its functional capacities.

Authors:  J J Weis; S A Richards; J A Smith; D T Fearon
Journal:  J Immunol Methods       Date:  1986-08-21       Impact factor: 2.303

3.  Enhancement of human B cell proliferation by an antibody to the C3d receptor, the gp 140 molecule.

Authors:  R Frade; M C Crevon; M Barel; A Vazquez; L Krikorian; C Charriaut; P Galanaud
Journal:  Eur J Immunol       Date:  1985-01       Impact factor: 5.532

4.  Growth control of activated, synchronized murine B cells by the C3d fragment of human complement.

Authors:  F Melchers; A Erdei; T Schulz; M P Dierich
Journal:  Nature       Date:  1985 Sep 19-25       Impact factor: 49.962

5.  Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

Authors:  J D Fingeroth; J J Weis; T F Tedder; J L Strominger; P A Biro; D T Fearon
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

6.  Identification of the membrane receptor for the complement fragment C3d by means of a monoclonal antibody.

Authors:  K Iida; L Nadler; V Nussenzweig
Journal:  J Exp Med       Date:  1983-10-01       Impact factor: 14.307

7.  Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin.

Authors:  G D Ross; S L Newman; J D Lambris; J E Devery-Pocius; J A Cain; P J Lachmann
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

8.  Two different complement receptors on human lymphocytes. One specific for C3b and one specific for C3b inactivator-cleaved C3b.

Authors:  G D Ross; M J Polley; E M Rabellino; H M Grey
Journal:  J Exp Med       Date:  1973-10-01       Impact factor: 14.307

9.  Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes.

Authors:  M E Medof; K Iida; C Mold; V Nussenzweig
Journal:  J Exp Med       Date:  1982-12-01       Impact factor: 14.307

10.  Human genes for three complement components that regulate the activation of C3 are tightly linked.

Authors:  S Rodriguez de Cordoba; D M Lublin; P Rubinstein; J P Atkinson
Journal:  J Exp Med       Date:  1985-05-01       Impact factor: 14.307
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  6 in total

1.  Membrane cofactor protein of complement is present on human fibroblast, epithelial, and endothelial cells.

Authors:  T McNearney; L Ballard; T Seya; J P Atkinson
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

2.  Neoantigens in complement component C3 as detected by monoclonal antibodies. Mapping of the recognized epitopes by synthetic peptides.

Authors:  B Nilsson; K Nilsson Ekdahl; D Avila; U R Nilsson; J D Lambris
Journal:  Biochem J       Date:  1990-05-15       Impact factor: 3.857

3.  Epstein-Barr virus regulates activation and processing of the third component of complement.

Authors:  C Mold; B M Bradt; G R Nemerow; N R Cooper
Journal:  J Exp Med       Date:  1988-09-01       Impact factor: 14.307

4.  CD46 knock-out using CRISPR/Cas9 editing of hTERT immortalized human cells modulates complement activation.

Authors:  Matthias Wieser; Teresa Francisci; Daniel Lackner; Tilmann Buerckstuemmer; Kamilla Wasner; Wolf Eilenberg; Anton Stift; Markus Wahrmann; Georg A Böhmig; Johannes Grillari; Regina Grillari-Voglauer
Journal:  PLoS One       Date:  2019-04-08       Impact factor: 3.240

5.  Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.

Authors:  J J Weis; L E Toothaker; J A Smith; J H Weis; D T Fearon
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307

Review 6.  Therapeutic uses of recombinant complement protein inhibitors.

Authors:  K R Kalli; P Hsu; D T Fearon
Journal:  Springer Semin Immunopathol       Date:  1994
  6 in total

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