Literature DB >> 24371430

Biosynthesis and Total Synthesis Studies on The Jadomycin Family of Natural Products.

Ehesan U Sharif1, George A O'Doherty1.   

Abstract

Jadomycins are unique angucycline polyketides, which are produced by soil bacteria Streptomyces venezuelae under specific nutrient and environmental conditions. Their unique structural complexity and biological activities have engendered extensive study of the jadomycin class of natural compounds in terms of biological activity, biosynthesis, and synthesis. This review outlines the recent developments in the study of the synthesis and biosynthesis of jadomycins.

Entities:  

Keywords:  Biosynthesis; Carbasugar; Digitoxose; Jadomycin; Phenanthridine Ring System; Total Synthesis

Year:  2012        PMID： 24371430      PMCID： PMC3871192          DOI： 10.1002/ejoc.201101609

Source DB:  PubMed          Journal:  European J Org Chem        ISSN： 1099-0690


  50 in total

1.  Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides.

Authors:  G Meurer; M Gerlitz; E Wendt-Pienkowski; L C Vining; J Rohr; C R Hutchinson
Journal:  Chem Biol       Date:  1997-06

2.  Novel jadomycins: incorporation of non-natural and natural amino acids.

Authors:  David L Jakeman; Spring Farrell; Wendy Young; René J Doucet; Shannon C Timmons
Journal:  Bioorg Med Chem Lett       Date:  2005-03-01       Impact factor: 2.823

3.  Physiology of antibiotic production in actinomycetes and some underlying control mechanisms.

Authors:  J L Doull; L C Vining
Journal:  Biotechnol Adv       Date:  1990       Impact factor: 14.227

4.  Jadomycins derived from the assimilation and incorporation of norvaline and norleucine.

Authors:  Stephanie N Dupuis; Thomas Veinot; Susan M A Monro; Susan E Douglas; Raymond T Syvitski; Kerry B Goralski; Sherri A McFarland; David L Jakeman
Journal:  J Nat Prod       Date:  2011-11-03       Impact factor: 4.050

5.  Syntheses of four D- and L-hexoses via diastereoselective and enantioselective dihydroxylation reactions.

Authors:  J M Harris; M D Keränen; H Nguyen; V G Young; G A O'Doherty
Journal:  Carbohydr Res       Date:  2000-08-18       Impact factor: 2.104

6.  De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin.

Authors:  Maoquan Zhou; George A O'Doherty
Journal:  J Org Chem       Date:  2007-03-06       Impact factor: 4.354

7.  Sharpless asymmetric dihydroxylation of 5-aryl-2-vinylfurans: application to the synthesis of the spiroketal moiety of papulacandin D.

Authors:  D Balachari; G A O'Doherty
Journal:  Org Lett       Date:  2000-03-23       Impact factor: 6.005

8.  Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae.

Authors:  Keqian Yang; Lei Han; Stephen W Ayer; Leo C Vining
Journal:  Microbiology (Reading)       Date:  1996-01       Impact factor: 2.777

9.  De novo synthesis of the trisaccharide subunit of landomycins A and E.

Authors:  Maoquan Zhou; George A O'Doherty
Journal:  Org Lett       Date:  2008-05-08       Impact factor: 6.005

10.  Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.

Authors:  Steven T Pullan; Govind Chandra; Mervyn J Bibb; Mike Merrick
Journal:  BMC Genomics       Date:  2011-04-04       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.