B Sharma, A Kalwar1, N Sharma, A Kapoor, N Kumar. 1. Department of Medical Oncology, Acharya Tulsi Regional Cancer Treatment and Research Institute and S.P. Medical College, Bikaner, Rajasthan, India.
Abstract
BACKGROUND: In our institute, about 10% of total cancer is female breast cancer. This analysis was performed to check triple negativity among these patients with their survival strength up to 5 years in relation to different age groups, stage and chemotherapy protocols. MATERIALS AND METHODS: 208 immunohistochemistry proved triple negative breast cancer patients registered and treated until 2008 were retrospectively selected for the study. Overall survival up to 5 years was observed on the basis of stage, different age groups and chemotherapy regimens. All patients had undergone surgery, conventional external beam radiation therapy and adjuvant chemotherapy. The survival analyses were performed using the Kaplan-Meier method. RESULTS: The majority of patients (41%) were in the age group 21-30 years. Stage IV was seen in 18% of the patients at diagnosis and mainly in 21-40 years age group. Only 3% of females were >70 years age and were of Stage I and II. Overall 5 year survival in Stage I in Cyclophosphamide, Adriamycin/Epirubicin, 5-Flurouracil group was 37.5% as compared with Docetaxel/Paclitaxel, Epirubicin group 93% (P < 0.0001). CONCLUSION: Triple negativity in North-West India is about 11.8%. We observed it in younger patients mainly with highly aggressive behaviors. Taxane based chemotherapy gives better result as compared with anthracycline based regimens in all stages.
BACKGROUND: In our institute, about 10% of total cancer is female breast cancer. This analysis was performed to check triple negativity among these patients with their survival strength up to 5 years in relation to different age groups, stage and chemotherapy protocols. MATERIALS AND METHODS: 208 immunohistochemistry proved triple negative breast cancerpatients registered and treated until 2008 were retrospectively selected for the study. Overall survival up to 5 years was observed on the basis of stage, different age groups and chemotherapy regimens. All patients had undergone surgery, conventional external beam radiation therapy and adjuvant chemotherapy. The survival analyses were performed using the Kaplan-Meier method. RESULTS: The majority of patients (41%) were in the age group 21-30 years. Stage IV was seen in 18% of the patients at diagnosis and mainly in 21-40 years age group. Only 3% of females were >70 years age and were of Stage I and II. Overall 5 year survival in Stage I in Cyclophosphamide, Adriamycin/Epirubicin, 5-Flurouracil group was 37.5% as compared with Docetaxel/Paclitaxel, Epirubicin group 93% (P < 0.0001). CONCLUSION: Triple negativity in North-West India is about 11.8%. We observed it in younger patients mainly with highly aggressive behaviors. Taxane based chemotherapy gives better result as compared with anthracycline based regimens in all stages.
Authors: Gunadala Ishitha; Marie Therese Manipadam; Selvamani Backianathan; Raju Titus Chacko; Deepak Thomas Abraham; Paul Mazhuvanchary Jacob Journal: J Clin Diagn Res Date: 2016-09-01
Authors: Suryanarayana V S Deo; Nootan Kumar Shukla; Ajay Gogia; Daya Nand Sharma; Ashish Jakhetiya; Dillip Kumar Muduly; Pankaj Kumar Garg; Sandeep R Mathur; V S Reenivas Journal: Indian J Surg Oncol Date: 2017-02-27