Literature DB >> 2436038

A mechanism by which adenovirus virus-associated RNAI controls translation in a transient expression assay.

G Akusjärvi, C Svensson, O Nygård.   

Abstract

The mechanism by which adenovirus virus-associated RNAI stimulates translational efficiency in a transient-expression assay in 293 cells was investigated. We showed that DNA transfection leads to activation of a protein kinase that phosphorylates the alpha subunit of eucaryotic initiation factor 2 and, as a consequence, inhibition of polypeptide chain initiation. Cotransfection of a plasmid encoding adenovirus type 2 virus-associated RNAI recovered the translational capacity by preventing activation of the kinase.

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Year:  1987        PMID： 2436038      PMCID： PMC365102          DOI： 10.1128/mcb.7.1.549-551.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  24 in total

1.  Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor.

Authors:  M Wigler; A Pellicer; S Silverstein; R Axel
Journal:  Cell       Date:  1978-07       Impact factor: 41.582

2.  Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase.

Authors:  J Kitajewski; R J Schneider; B Safer; S M Munemitsu; C E Samuel; B Thimmappaya; T Shenk
Journal:  Cell       Date:  1986-04-25       Impact factor: 41.582

3.  Synthesis of complementary RNA sequences during productive adenovirus infection.

Authors:  U Pettersson; L Philipson
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

4.  A mechanism for the control of protein synthesis by adenovirus VA RNAI.

Authors:  R P O'Malley; T M Mariano; J Siekierka; M B Mathews
Journal:  Cell       Date:  1986-02-14       Impact factor: 41.582

5.  The use of rRNA-cellulose chromatography in the rapid isolation of homogeneous protein synthesis initiation factor eIF-2 from rat liver microsomes.

Authors:  O Nygård; P Westermann; T Hultin
Journal:  Biochim Biophys Acta       Date:  1980-06-27

6.  RNA of low molecular weight in KB cells infected with adenovirus type 2.

Authors:  P R Reich; B G Forget; S M Weissman
Journal:  J Mol Biol       Date:  1966-06       Impact factor: 5.469

7.  A new species of virus-coded low molecular weight RNA from cells infected with adenovirus type 2.

Authors:  H Söderlund; U Pettersson; B Vennström; L Philipson; M B Mathews
Journal:  Cell       Date:  1976-04       Impact factor: 41.582

8.  Defective RNA splicing in the absence of adenovirus-associated RNAI.

Authors:  C Svensson; G Akusjärvi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

9.  Genes for VA-RNA in adenovirus 2.

Authors:  M B Mathews
Journal:  Cell       Date:  1975-10       Impact factor: 41.582

10.  Adenovirus VA RNAI mediates a translational stimulation which is not restricted to the viral mRNAs.

Authors:  C Svensson; G Akusjärvi
Journal:  EMBO J       Date:  1985-04       Impact factor: 11.598
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  29 in total

1.  Inhibition of the protein kinase PKR by the internal ribosome entry site of hepatitis C virus genomic RNA.

Authors:  Jashmin Vyas; Androulla Elia; Michael J Clemens
Journal:  RNA       Date:  2003-07       Impact factor: 4.942

2.  Translational stimulation by reovirus polypeptide sigma 3: substitution for VAI RNA and inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

Authors:  R M Lloyd; A J Shatkin
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

3.  The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.

Authors:  R J Kaufman; M V Davies; V K Pathak; J W Hershey
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

4.  Suppression of RNA interference by adenovirus virus-associated RNA.

Authors:  M Gunnar Andersson; P C Joost Haasnoot; Ning Xu; Saideh Berenjian; Ben Berkhout; Göran Akusjärvi
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

5.  Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

Authors:  G D Ghadge; S Swaminathan; M G Katze; B Thimmapaya
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

6.  Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.

Authors:  W J Chen; D A Andres; J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

7.  The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.

Authors:  Megan E Spurgeon; David A Ornelles
Journal:  J Virol       Date:  2009-07-15       Impact factor: 5.103

8.  Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor.

Authors:  M V Davies; M Furtado; J W Hershey; B Thimmappaya; R J Kaufman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

9.  Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

Authors:  J Ye; U P Davé; N V Grishin; J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

10.  Reovirus polypeptide sigma 3 and N-terminal myristoylation of polypeptide mu 1 are required for site-specific cleavage to mu 1C in transfected cells.

Authors:  L Tillotson; A J Shatkin
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103
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