Literature DB >> 24359917

Insights into the structure of class B GPCRs.

Kaspar Hollenstein1, Chris de Graaf2, Andrea Bortolato1, Ming-Wei Wang3, Fiona H Marshall4, Raymond C Stevens5.   

Abstract

The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (such as type 2 diabetes, osteoporosis, and obesity) and nervous system diseases (such as migraine, anxiety, and depression). The recently solved crystal structures of the transmembrane domains of the human glucagon receptor and human corticotropin-releasing factor receptor 1 have opened up new opportunities to study the structure and function of class B GPCRs. The current review shows how these structures offer more detailed explanations to previous biochemical and pharmacological studies of class B GPCRs, and provides new insights into their interactions with ligands.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  class B G protein-coupled receptor (GPCR); corticotropin-releasing factor receptor 1 (CRF(1)); crystal structure; glucagon receptor (GCGR); ligand binding

Mesh：

Substances：

Year:  2013        PMID： 24359917      PMCID： PMC3931419          DOI： 10.1016/j.tips.2013.11.001

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  69 in total

Review 1.  Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors.

Authors:  Sam R J Hoare
Journal:  Drug Discov Today       Date:  2005-03-15       Impact factor: 7.851

2.  Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.

Authors:  Sam R J Hoare; Brock T Brown; Mark A Santos; Siobhan Malany; Stephen F Betz; Dimitri E Grigoriadis
Journal:  Biochem Pharmacol       Date:  2006-04-25       Impact factor: 5.858

3.  Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand.

Authors:  Christy Rani R Grace; Marilyn H Perrin; Jozsef Gulyas; Michael R Digruccio; Jeffrey P Cantle; Jean E Rivier; Wylie W Vale; Roland Riek
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-12       Impact factor: 11.205

4.  Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.

Authors:  E Schipani; G S Jensen; J Pincus; R A Nissenson; T J Gardella; H Jüppner
Journal:  Mol Endocrinol       Date:  1997-06

5.  Localization of ligand-binding domains of human corticotropin-releasing factor receptor: a chimeric receptor approach.

Authors:  C W Liaw; D E Grigoriadis; T W Lovenberg; E B De Souza; R A Maki
Journal:  Mol Endocrinol       Date:  1997-06

6.  Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor.

Authors:  M A Cascieri; G E Koch; E Ber; S J Sadowski; D Louizides; S E de Laszlo; C Hacker; W K Hagmann; M MacCoss; G G Chicchi; P P Vicario
Journal:  J Biol Chem       Date:  1999-03-26       Impact factor: 5.157

7.  Constitutive activity of glucagon receptor mutants.

Authors:  S A Hjorth; C Orskov; T W Schwartz
Journal:  Mol Endocrinol       Date:  1998-01

8.  Mutations of aromatic residues in the first transmembrane helix impair signalling by the secretin receptor.

Authors:  E Di Paolo; H Petry; N Moguilevsky; A Bollen; P De Neef; M Waelbroeck; P Robberecht
Journal:  Receptors Channels       Date:  1999

9.  Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin.

Authors:  E Di Paolo; P De Neef; N Moguilevsky; H Petry; A Bollen; M Waelbroeck; P Robberecht
Journal:  FEBS Lett       Date:  1998-03-13       Impact factor: 4.124

10.  Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

Authors:  Chaohong Sun; Danying Song; Rachel A Davis-Taber; Leo W Barrett; Victoria E Scott; Paul L Richardson; Ana Pereda-Lopez; Marie E Uchic; Larry R Solomon; Marc R Lake; Karl A Walter; Philip J Hajduk; Edward T Olejniczak
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-30       Impact factor: 11.205
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  71 in total

Review 1.  Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.

Authors:  Chris de Graaf; Dan Donnelly; Denise Wootten; Jesper Lau; Patrick M Sexton; Laurence J Miller; Jung-Mo Ahn; Jiayu Liao; Madeleine M Fletcher; Dehua Yang; Alastair J H Brown; Caihong Zhou; Jiejie Deng; Ming-Wei Wang
Journal:  Pharmacol Rev       Date:  2016-10       Impact factor: 25.468

2.  Pituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships.

Authors:  Charles G Starr; Jerome L Maderdrut; Jing He; David H Coy; William C Wimley
Journal:  Peptides       Date:  2018-04-11       Impact factor: 3.750

3.  Structure of the glucagon receptor in complex with a glucagon analogue.

Authors:  Haonan Zhang; Anna Qiao; Linlin Yang; Ned Van Eps; Klaus S Frederiksen; Dehua Yang; Antao Dai; Xiaoqing Cai; Hui Zhang; Cuiying Yi; Can Cao; Lingli He; Huaiyu Yang; Jesper Lau; Oliver P Ernst; Michael A Hanson; Raymond C Stevens; Ming-Wei Wang; Steffen Reedtz-Runge; Hualiang Jiang; Qiang Zhao; Beili Wu
Journal:  Nature       Date:  2018-01-03       Impact factor: 49.962

4.  Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).

Authors:  Dehua Yang; Chris de Graaf; Linlin Yang; Gaojie Song; Antao Dai; Xiaoqing Cai; Yang Feng; Steffen Reedtz-Runge; Michael A Hanson; Huaiyu Yang; Hualiang Jiang; Raymond C Stevens; Ming-Wei Wang
Journal:  J Biol Chem       Date:  2016-04-08       Impact factor: 5.157

5.  Impact of Substitution Registry on the Receptor-Activation Profiles of Backbone-Modified Glucagon-like Peptide-1 Analogues.

Authors:  Brian P Cary; Marlies V Hager; Samuel H Gellman
Journal:  Chembiochem       Date:  2019-09-20       Impact factor: 3.164

Review 6.  Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles.

Authors:  Debbie L Hay; Augen A Pioszak
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-23       Impact factor: 13.820

7.  Allostery: A GPCR's back door.

Authors:  Klaus Mohr; Evi Kostenis
Journal:  Nat Chem Biol       Date:  2014-08       Impact factor: 15.040

8.  Pituitary adenylate cyclase-activating polypeptide (PACAP) protects against mitoxantrone-induced cardiac injury in mice.

Authors:  Venkat Subramaniam; Gin Chuang; Huijing Xia; Brendan Burn; Jessica Bradley; Jerome L Maderdrut; David H Coy; Kurt J Varner
Journal:  Peptides       Date:  2017-07-15       Impact factor: 3.750

9.  Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Authors:  Gaojie Song; Dehua Yang; Yuxia Wang; Chris de Graaf; Qingtong Zhou; Shanshan Jiang; Kaiwen Liu; Xiaoqing Cai; Antao Dai; Guangyao Lin; Dongsheng Liu; Fan Wu; Yiran Wu; Suwen Zhao; Li Ye; Gye Won Han; Jesper Lau; Beili Wu; Michael A Hanson; Zhi-Jie Liu; Ming-Wei Wang; Raymond C Stevens
Journal:  Nature       Date:  2017-05-17       Impact factor: 49.962

Review 10.  Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors.

Authors:  Wijnand J C van der Velden; Laura H Heitman; Mette M Rosenkilde
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-18
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